Mechanisms of early ciliogenesis (A01)

• Subject Area: Nephrology ; Nuclear Medicine, Radiotherapy, Radiobiology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

Primary cilia have limited function in an ever increasing number of illnesses, now also known as ciliopathies. The underlying pathogenetic processes can only be understood if the formation of primary cilia is extensively characterized. According to findings made during the ongoing funding period endocytosis and the Golgi apparatus are important for ciliogenesis. In the current proposal we want to investigate in what way endocytotic processes contribute to the formation of cilia, when the Golgi apparatus is involved, which proteins are active at the Golgi apparatus and which proteins facilitate the docking and the fusion of transport vesicles at the mother centriole.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Head: Professor Dr. Ralph Witzgall