Renal ENaC regulation by the transmembrane serine protease TMPRSS2 and structure-based analysis of proteolytic channel activation (A04)

• Subject Area: Anatomy and Physiology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

Recently, we identified TMPRSS2 as novel candidate protease to activate the epithelial sodium channel (ENaC) by proteolytic cleavage. We aim to elucidate the role of TMPRSS2 in renal ENaC regulation and gain further insights into the complex molecular mechanisms of proteolytic and non-proteolytic ENaC activation. A better understanding of ENaC function at the molecular level may lead to novel (patho-) physiological and therapeutic concepts for renal disorders involving increased ENaC activity and renal salt retention.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Alexandr Ilyaskin, Ph.D.; Professor Dr. Christoph Korbmacher