Myeloid cell–regulatory T cell crosstalk in thrombus development and resolution (A10)

• Subject Area: Immunology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 490846870

Immune and vascular cells sense proteolytic activity through protease-activated receptors (PARs) and these pathways contribute to regeneration following injury. We will analyze how PAR signaling regulated the development and activation of a specialized population of Treg cells that imposes functional changes on the myeloid compartment in clot resolution. With unique PAR mutant knock-in mouse models, cell-type specific PAR deletion, and mice with altered coagulation control, we will determine which signals in the clot emanate from myeloid cells to regulate tissue repair Treg cells and their reciprocal crosstalk.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 355: Heterogeneity and functional specialization of regulatory T cells in distinct microenvironments
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Tobias Bopp; Professor Dr. Wolfram Ruf