Project Details
Projekt
Proximal tubular signals as determinants of renal inflammation and fibrosis (A07)
Subject Area
Anatomy and Physiology
Nephrology
Cell Biology
Nephrology
Cell Biology
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993
In recent years, we have investigated the pathophysiology of GATM- and EHD1-related monogenetic diseases involving proximal tubular mitochondria and intracellular vesicle dynamics, respectively. Here, we will investigate the role of EHD1 in intracellular membrane shaping and dynamics and the adaptive mechanisms underlying the mild phenotype of GATM knockin mice. The expected results will help to elucidate the functional principles of proximal tubule adaptation and maladaptation and ideally lead to the development of a therapeutic approach for GATM-associated Fanconi syndrome.
DFG Programme
CRC/Transregios
Subproject of
TRR 374:
Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
Applicant Institution
Universität Regensburg
