Anti-inflammatory and tissue-protective effects of 2-oxoglutarate-dependent dioxygenase inhibition in progressive kidney disease (B05)

• Subject Area: Nephrology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

In the last funding period, we found that 2-oxoglutarate dioxygenase inhibitors (2OGDi) reduce inflammation in the mouse adenine nephropathy model. According to our results, we hypothesize that 2OGDi-mediated inflammasome-inhibition reduces chronic renal inflammation, which requires immunoregulatory and renoprotective effects of immunoregulatory Nr4a1-positive mononuclear phagocytes (MNPs). In this funding period, we will investigate the role of intracellular Ca2+ balance and adenylate cyclases on 2OGDi-mediated inflammasome inhibition and we will explore the role of Nr4a1-positive MNPs in 2OGDi-dependent renoprotection.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Professor Dr. Jonathan Jantsch; Dr. Gunnar Schley; Professor Dr. Carsten Willam