Modulation of T-/B-lymphocyte immigration affects subsequent allograft damage (B06)

• Subject Area: Nephrology
• Term: Funded in 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

Due to the clinical need for sustainable treatment of antibody-mediated rejection and the pivotal role of B cells in this context, we will move forward with our well-characterized renal transplantation (RTx) model in rats. We plan to investigate the synergistic effects of a T-cell depleting and anti-BAFF receptor therapy for prevention of rejection in pre-immunized recipients as well as on the secretion of Dickkopf 3 (DKK3), which has been recently characterized regarding its relevance in transplantation medicine. As a perspective, we want to examine the effects of DKK3 silencing in an experimental RTx model with regard to prevention of development of interstitial fibrosis and tubular atrophy.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Privatdozent Dr. Tobias Bergler; Dr. Louisa Steines