Role of renal dendritic cell subpopulations in the inflammatory environment of acute kidney injury and kidney transplantation (B07*)

• Subject Area: Immunology ; Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

This project aims to investigate the role and interplay of dendritic cell (DC) and tubular epithelial cell subpopulations during ischemia-reperfusion and renal transplantation in mice. DCs are among the first immune cells to respond to danger signals in the transplant environment. Understanding the signals of stressed tubular epithelial cells to the different DC subpopulations of donor and recipient will help identify the network of signals for the development of more specific and less toxic immunosuppressants in the future.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Professorin Dr. Diana Dudziak; Privatdozent Dr. Andre Hörning; Professor Dr. Carsten Willam