Uromodulin-NET-complement interaction in tubulointerstitial injury (C02)

• Subject Area: Pathology ; Nephrology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

This project aims to investigate the role and interaction of uromodulin (UMOD), neutrophil extracellular traps (NET) and the complement system in inflammatory and non-inflammatory tubulointerstitial kidney disease. To this end, we will investigate the presence, abundance and interaction of these three factors and their effects on inflammatory processes, fibrosis and renal function in human kidney biopsies, animal and in vitro models. Using inhibitor and knockout strategies, we will assess whether modulation of UMOD-NET-complement interaction could represent a new therapeutic target in tubulointerstitial kidney disease.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Professorin Dr. Kerstin Amann; Dr. Maike Büttner-Herold; Professor Dr. Christoph Daniel