The epigenetic memory of renal tubular cells (C05)

• Subject Area: Nephrology ; Anatomy and Physiology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

Epigenetic and transcriptional mechanisms in tubular cells governing acute kidney injuries and transition to chronic disease are only understood rudimentary, but may relate to important signaling pathways involved in promoting fibrosis such as hypoxia or inflammation. In order to analyze how hypoxia shapes an epigenetic memory in the tubular system, we will perform experiments in mice and isolated human primary cells using state-of-the-art genome-wide sequencing techniques. We will intersect this data with genetic predisposition studies to define mechanisms that might be susceptible to therapy in the future.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Dr. Steffen Grampp; Johannes Schödel, Ph.D.