3D-in-ovo-model to study and modulate the growth of human renal cystic tissue and mouse kidney slices (C08*)

• Subject Area: Nuclear Medicine, Radiotherapy, Radiobiology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

The overall aim of our project is the translation of our findings of mechanisms of cyst growth resulting from animal models into clinical applications for the treatment of patients. We want to overcome this huge gap by introducing an intermediate model that allows us to monitor human cyst growth ex vivo and test promising drugs regarding their efficacy in human ADPKD tissue using the chorioallantoic membrane (CAM) model. Furthermore, the successful cultivation of vital adult mouse kidney tissue on the CAM may enable us to expand our studies to additional aspects of renal (patho-) physiology ex vivo.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Professor Dr. Thiha Aung; Privatdozent Dr. Björn Buchholz; Professorin Dr. Silke Härteis