Project Details
Projekt
Role of Neuropilin-1 on Lung Macrophages during Pulmonary Inflammation
Applicants
Professor Dr. Johannes Andreas Eble; Professor Dr. Alexander Zarbock, since 6/2023
Subject Area
Anaesthesiology
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 414847370
This project will investigate the role of Nrp1-ligands on monocyte recruitment and macrophage polarization in the lung. In this project proposal, the principal investigators aim to provide novel insight into the molecular interactions and signaling partners of Nrp1 on macrophages and to characterize the role of myelo-monocytic Nrp1 in the pathobiology of acute pulmonary inflammation and resolution. Ultimately, the results will initiate the translation of the findings into the development of an Nrp1 inhibitor which preferentially targets lung macrophages for therapeutic benefit.
DFG Programme
Clinical Research Units
Subproject of
KFO 342:
Organ Dysfuncion During Systemic Inflammation
Ehemalige Antragstellerin
Dr. Catharina Conrad, until 6/2023
