Molekulare Mechanismen der Aktivierung eosinophiler Granulozyten durch Interleukin-4 und Interleukin-13 beim Asthma bronchiale

Applicant Professor Dr. Karlheinz Friedrich

Subject Area Pneumology, Thoracic Surgery

Term from 2000 to 2011

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 5227854

Final Report Year 2009

Final Report Abstract

No abstract available

A microscale assay for the identification of TGF-ß antagonists based on functional coupling of the heterodimeric TGF-ß receptor to STAT6-driven promoter activation. Signal Transduction 4: 55-9 (2005)
Krause, S.; Friedrich, K.
Blockade of interleukin-13-mediated cell activation by a novel inhibitory antibody to human IL-13 receptor α 1. Mol. Immunol. 43:1799-807 (2006)
Krause, S.; Behrends, J.; Borowski, A.; Lohrmann, J.; Lang, S.; Myrtek, D.; Lorenzen, T.; Virchow, J.C.; Luttmann, W.; Friedrich, K.
Specific inhibition of interleukin-13 activity by a recombinant human single-chain immunoglobulin domain directed against the IL-13 receptor alphal chain. Biol. Chem. 388:325-30 (2007)
Knackmuss, S.; Krause, S.; Engel, K.; Reusch, U.; Virchow, J.C; Mueller, T.; Kraich, M.; Little, M.; Luttmann, W.; Friedrich, K.
Interleukin-13 promotes pro-fibrotic parameters in epithelia and fibroblasts of the human lung. Clin. Exp. Allergy 38:619-28 (2008)
Borowski, A.; Kuepper, M.; Horn, U.; Knüpfer, U.; Zissel, G.; Höhne, K.; Luttmann, W.; Krause, S.; Virchow, J.C.; Friedrich, K.
Safety of segmental allergen challenge in human allergic asthma. J Allergy Clin Immunol. 121:712- 72 (2008)
Julius, P.; Lommatzsch, M.; Kuepper, M.; Bratke, K.; Faehndrich, S.; Luttmann, W.; Virchow, J.C.