Mapping and targeting neuron-tumor networks to tackle therapy resistance in clioblastoma (A07*)

• Subject Area: Hematology, Oncology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 404521405

The contribution of neuron-glioma synapses to resistance against chemo- and radiotherapy will be studied using state-of-the-art imaging technologies that allow for high-throughput screening and analyses of tumor-neuron networks. Molecular determinants of neuron-tumor synapses are analyzed through multi-omics in both preclinical models and patient material. We aim to identify if disrupting neuron-tumor synapses can be synergistically used with standard-of-care approaches to overcome therapy resistance.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1389: Understanding and Targeting Resistance in Glioblastoma (UNITE Glioblastoma)
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Dr. Matthia Karreman; Dr. Varun Venkataramani