Personalized Glioblastoma treatment fuided by patient-derived tumor organoids (A08*)

• Subject Area: Hematology, Oncology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 404521405

This project leverages recently established human glioblastoma organoid models to lay the groundwork for future molecularly stratified studies. We will integrate patient-derived organoids to drug screening pipelines to complement druggable target prioritization from molecular profiling. Using single-cell genomics, we will longitudinally map the clonal evolution of treatment-sensitive and resistant organoids to dissect the genetic and transcriptional mechanisms of resistance.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1389: Understanding and Targeting Resistance in Glioblastoma (UNITE Glioblastoma)
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Privatdozentin Dr. Aurélie Ernst; Hai-Kun Liu, Ph.D.