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Personalized Glioblastoma treatment fuided by patient-derived tumor organoids (A08*)

Subject Area Hematology, Oncology
Term since 2023
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 404521405
 
This project leverages recently established human glioblastoma organoid models to lay the groundwork for future molecularly stratified studies. We will integrate patient-derived organoids to drug screening pipelines to complement druggable target prioritization from molecular profiling. Using single-cell genomics, we will longitudinally map the clonal evolution of treatment-sensitive and resistant organoids to dissect the genetic and transcriptional mechanisms of resistance.
DFG Programme Collaborative Research Centres
 
 

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