Functional Characterization of EGFR structural variants associated with long-term survival in glioblastoma, IDH-wt (C06*)

• Subject Area: Hematology, Oncology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 404521405

In the subproject we profiled MGMT-promoter methylated glioblastomas, IDH-wt and identified unusual out-of-frame EGFR fusions and exon deletions in glioblastomas with long-term survival. Using mass-spectrometry based interactomics and phosphoproteomics we aim at elucidating the underlying mechanism. Candidate mechanisms will be validated in functional assays. We will evaluate the possibility to mimic the identified mechanism of signaling modification by specific drugs and test the effectiveness in pre-clinical model systems.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1389: Understanding and Targeting Resistance in Glioblastoma (UNITE Glioblastoma)
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professor Dr. Andreas von Deimling; Privatdozent Dr. David E. Reuß