Mutationen am GnRH Rezeptor Gen bei IHH (Idiopathic Hypogonadotropic Hypogonadism) Patienten/ Projekt auf 2 Ebenen: 1. Phenotyp, 2. Genotyp

• Antragstellerin: Dr. Astrid Meysing
• Fachliche Zuordnung: Gynäkologie und Geburtshilfe
• Förderung: Förderung von 2000 bis 2005
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5267730

To further elucidate the physiology and pathology of reproductive function and at the same time improve diagnosis and treatment in the reproductive field, this project plans a two leveled approach to the disorder idiopathic hypogonadotropic hypogonadism (IHH) at a leading research institution of Harvard Medical School, the Massachusetts General Hospital, Boston/USA. Both female and male IHH patients present a broad variety of symptoms and a different range of responses to exogenous GnRH replacement. Consequently this project plans to combine phenotyping (including GnRH pump studies) and genotyping in IHH patients by both carefully evaluating the patient and searching for new mutations in the GnRH receptor gene. In the long run this 2 years project will not only establish a phenotype/genotype database that will allow to analyse the mechanisms of producing this condition, improve diagnosis and treatment of such disease, but also be a strong foundation to proceed with future research projects back in Germany concerning a molecular exploration and analysis of illness.

• DFG-Verfahren: Forschungsstipendien
• Internationaler Bezug: USA