Angiotensin II-induzierte Entzündungsreaktionen und ihre Kontrolle durch P450-abhängige Metabolite mehrfach ungesättigter Fettsäuren

• Antragsteller: Professor Dr. Dominik N. Müller
• Fachliche Zuordnung: Nephrologie
• Förderung: Förderung von 2001 bis 2008
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5288206

• Erstellungsjahr: 2008

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activators. Hypertension 2002, 39:609-613
  Lauterbach B, Barbosa-Sicard E, Wang MH, Honeck H, Kargel E, Theuer J, Schwartzman ML, Haller H, Luft FC. Gollasch M, Schunck WH
  
• Immunosuppressive treatment protects against angiotensin Il-induced renal damage. Am J Pathol 2002, 161:1'679-1693
  Muller DN, Shagdarsuren E, Park JK, Dechend R, Mervaala E, Hampich F, Fiebeler A, Ju X, Finckenberg P, Theuer J, Viedt C, Kreuzer J, Heidecke H, Haller H, Zenke M, Luft FC
  
• P450-dependent arachidonic acid metabolism and angiotensin Il-induced renal damage. Hypertension 2002, 40:273-279
  Kaergel E, Muller DN, Honeck H, Theuer J, Shagdarsuren E, Mullally A, Luft FC, Schunck WH
  
• Cytochrom P450-abhängiger Metabolismus der Arachidonsäure und Eicosapentaensäure. Dissertation Humboldt-Universität 2003
  Barbosa-Sicard E
  
• A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin Il-induced renal injury. Am J Pathol 2004, 164:521- 532
  Muller DN, Theuer J, Shagdarsuren E, Kaergel E, Honeck H, Park JK, Markovic M, Barbosa- Sicard E, Dechend R, Wellner M, Kirsch T, Fiebeler A, Rothe M, Haller H, Luft FC, Schunck WH
  
• Aldosterone Potentiates Angiotensin 11-Induced Signaling in Vascular Smooth Muscle Cells. Circulation 2004;109:2792-2800
  Mazak I, Fiebeler A, Muller DN, Park JK, Shagdarsuren E, Lindschau C, Dechend R, Viedt C, Pilz B, Haller H, Luft FC
  
• Arachidonic and eicosapentaenoic acid metabolism by CYPIAl: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid. Biochem Pharmacol 2004,67:1445-57
  Schwarz D, Kisselev P, Ericksen SS, Szklarz GD, Chemogolov A, Honeck H, Schunck WH, Roots I
  
• Agonistic autoantibodies to the ATI receptor in a transgenic rat model of preeclampsia. Hypertension 2005;45(4):742-6
  Dechend R, Gratze P, Wallukat G, Erdenechimeg S, Bräsen J-H, Schneider W, Fiebeler A, Plehm R, Caluwaerts S, Vercruysse L, Pijnenborg R, Luft FC, Müller DN
  
• An aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage. Circulation 2005;111:3087-94
  Fiebeler A, Nussberger J, Shagdarsuren E, Rong S, Hilfenhaus G, Al-Saadi N, Dechend R, Welber M, Meiners S, Maser-Gluth C, Jeng AY, Webb RL, Luft FC, Muller DN
  
• Association of CYPIAl polymorphisms with differential metabolic activation of 17beta-estradiol and estrone. Cancer Res. 2005 Apr 1;65(7):2972-8
  Kisselev P, Schunck WH, Roots I, Schwarz D
  
• Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily. Biochem Biophys Res Commun 2005;329(4):1275-81
  Barbosa-Sicard E, Markovic M, Honeck H, Christ B, Muller DN, Schunck WH
  
• Eicosapentaenoic acid supplementation, but not iNOS blockade, protects from angiotensin ll-induced renal damage. Kid Int 2005;67:248-58
  Theuer J, Shagdarsuren E, Muller DN, Kaergel E, Honeck H, Park J-K, Fiebeler A, Dechend R, Haller H, Luft FC, Schunck W-H
  
• Human CYPIAl variants lead to differential eicosapentaenoic acid metabolite patterns. Biochem Biophys Res Commun. 2005 ;336(3):779-83
  Schwarz D, Kisselev P, Chemogolov A, Schunck WH, Roots I
  
• Angiotensin II-induced sudden arrhythmic death and electrical remodeling. Am J Physiol Heart Circ Physiol. 2007;293:H1242-53
  Fischer R, Dechend R, Gapelyuk A, Shagdarsuren E, Gmner K, Grüner A, Gratze P, Qadri F, Welbier M, Fiebeler A, Dietz R, Luft FC, Muller DN, Schirdewan A
  
• COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia. Am J Physiol Heart Circ Physiol. 2007;293(4):H2148-54
  Birkenmeier K, Staudt A, Schunck WH, Janke I, Labitzke C, Prange T, Trimpert C, Krieg T, Landsberger M, Stangl V, Felix SB
  
• Dietary n-3 PUFA and direct renin inhibition improve electrical remodeling in angiotensin Il-induced cardiac injury. Hypertension. 2007; 51:540-6
  Fischer R, Dechend R, Qadri F, Markovic M, Feldt S, Herse F, Park J-K, Gapelyuk A, Schwarz I, Safak E, Heuser A, Schirdewan A, Luft FC, Schunck W-H, Muller DN
  
• Mouse Cyp4a isoforms: Enzymatic properties, genderand strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. Biochem J 2007;403(1):109-18
  Muller DN, Schmidt C, Barbosa-Sicard E, Wellner M, Gross V, Hercule H, Markovic M, Honeck H, Luft FC, Schunck W-H
  
• P38 mitogen-activated protein kinase inhibition ameliorates angiotensin Il-induced target organ damage. Hypertension 2007; 49:481-9
  Park J-K, Fischer R, Dechend R, Shagdarsuren E, Gapeljuk A, Wellner M, Meiners S, Gratze P, A!-Saadi N, Feldt S, Fiebeler A, Madwed JB, Schirdewan A, Haller H, Luft FC, Muller DN
  
• The vasodilator 17,18-epoxyeicosatetraenoic acid targets the poreforming BK alpha channel subunit in rodents. Exp Physiol. 2007;92:1067-76
  Hercule HC, Salanova B, Essin K, Honeck H, Falck JR, Sausbier M, Ruth P, Schunck WH, Luft FC, Gollasch M
  
• Cytochrome P450-dependent metabolism of eicosapentaenoic acid in the nematode Caenorhabditis elegans. Arch Biochem Biophys. 2008 Apr 1;472(1):65-75
  Kulas J, Schmidt C, Rothe M, Schunck WH, Menzel R
  
• Rapid signaling in vascular smooth muscle cells following corticosterone challenge and effects on vascular tone. Hypertension 2008; 51:1372-8
  Molnar GA, Lindschau C, Dubrovska G, Mertens PR, Gollasch M, Luft FC, Muller DN, Fiebeler A
  
• Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease. Nat Genet. 2008;40:529-37
  Monti J, Fischer J, Paskas S, Heinig M, Schulz H, Gösele C, Heuser A, Fischer R, Schmidt C, Schirdewan A, Gross V, Hummel O, Maatz H, Patone G, Saar K, Vingron M, Weldon SM, Lindpaintner K, Hammock BD, Rohde K, Dietz R, Cook SA, Schunck WH, Luft FC, Hubner N
  
• The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling. J Am Soc Nephrol. 2008; 19:743-8
  Feldt S, Maschke U, Dechend R, Luft FC, Muller DN
  
• Cytochrome P450-dependent eicosanoids. In: Cardiovascular Hormones, Bader M, ed., Wiley-VHC
  Schunck, WH, Schmidt C
  
• Identifizierung, molekulare Eigenschaften und Regulation einer renalen 20- Hydroxyeicosatetraensäure-Synthase. Dissertation, Humboldt-Universität Berlin
  Schmidt, C