Consequences of gut-imprinted immune cell trafficking for bone homeostasis (A03)

• Subject Area: Gastroenterology ; Immunology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 501752319

Inflammatory bowel disease is closely linked with bone loss and increased risk for osteoporosis and fractures. The project A03 will determine the complex interactions between the gut micromilieu and skeletal health. A03 aims to analyze the role of T cell activation in the gut and the subsequent trafficking of T cells from the gut to bone conveying articular inflammation and subsequent bone loss in patients with IBD.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 369: DIONE Degeneration of bone induced by inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Dr. Juliane Salbach-Hirsch; Professor Dr. Sebastian Zundler