The protective role of eosinophils against inflammatory bone loss (B03)

• Subject Area: Immunology ; Rheumatology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 501752319

Project B03 will define the role of eosinophils in regulating bone health has received little attention. Our initial findings indicate that eosinophils inhibit osteoclast formation and activity. This project aims to understand the cellular and molecular basis for the inhibitory effects of eosinophils on osteoclasts and to decipher the role of eosinophils in regulating arthritic bone loss in mice and humans to discover new therapeutic strategies to address this condition.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 369: DIONE Degeneration of bone induced by inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Head: Dr. Darja Andreev