Innate immune training-mediated regulation of osteoclasts and inflammatory bone loss (C03)

• Subject Area: Toxicology, Laboratory Medicine
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 501752319

Project C03 will analyze whether trained immunity may also affect osteoclast generation and function and how this might contribute to inflammatory bone loss. The overarching theme and long-term perspective of C03 is to show that diseases related to inflammatory bone loss are associated with "trained" bone-marrow progenitors, poised towards enhanced osteoclastogenesis and hence identify trained immunity-associated therapeutic targets.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 369: DIONE Degeneration of bone induced by inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Professor Dr. Triantafyllos Chavakis; Professorin Dr. Lydia Kalafati, Ph.D.