Strukturelle und funktionale Charakterisierung einer neuen Splice Variante des latenten transforming growth factor beta bindenden Proteins LTBP4

• Applicant: Professor Harald von Melchner, Ph.D.
• Subject Area: Hematology, Oncology
• Term: from 2001 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5323112

• Final Report Year: 2008

Final Report Abstract

No abstract available

Publications

• 2002: Disruption of the Gene Encoding the Latent Transforming Growth Factor b Binding Protein 4 (LTBP-4) Causes Abnormal Lung Development, Cardiomyopathy and Colorectal Cancer. Genes Dev, 16,2264-2273
  Sterner-Kock, A., I. S. Thorey, K. Koli, F. Wempe, J. Otte, T. Bangsow, K. Kuhlmeier, T. Kirchner, S. Jin, J. Keski-Oja, and H. von Melchner
  
• 2003: An animal model exhibiting cancer, pulmonary emphysema and cardiomyopathy. WO 03/015505 A3
  von Melchner, H., I. S. Thorey, F. Wempe. and J. Keski-Oja
  
• 2004: Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung. J Cell Biol, 167,123-33
  Koli, K., F. Wempe, A. Sterner-Kock, A. Kantola, M. Komor, W. K. Hofmann, H. von Melchner, and J. Keski-Oja
  
• 2004: TGF-beta activation by traction? Trends Cell Biol, 14, 657-9
  Keski-Oja, J., K. Koli, and H. von Melchner
  
• 2006: High-throughput trapping of secretory pathway genes in mouse embryonic stem cells. Nucleic Acids Res, 34, e25
  De-Zolt, S., F. Schnutgen, C. Seisenberger, J. Hansen, M. Hollatz, T. Floss, P. Ruiz, W. Wurst, and H. von Melchner
  
• 2008: An animal model for the selection of agents active against pulmonary emphysema and colorectal cancer. EP1900819 (A1)
  von Melchner, H., F. Wempe. and S. De-Zolt
  
• 2008: The epithelial membrane protein 1 is a novel tight junction protein of the blood-brain barrier. J Cereb Blood Flow Metab, 28, 1249-60
  Bangsow, T., E. Baumann, C. Bangsow, M. H. Jaeger, B. Pelzer, P. Gruhn, S. Wolf, H. von Melchner, and D. B. Stanimirovic
  
• 2008: Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell, 13, 407-19
  Petrova, T. V., A. Nykanen, C. Norrmen, K. I. Ivanov, L. C. Andersson, C. Haglund, P. Puolakkainen, F. Wempe, H. von Melchner, G. Gradwohl, S. Vanharanta, L. A. Aaltonen, J. Saharinen, M. Gentile, A. Clarke, J. Taipale, G. Oliver, and K. Alitalo
  
• 2008: Wnt/beta-Catenin signaling controls development and maintenance of the blood-brain barrier. J Cell Biol
  Liebner, S., M. Corada, T. Bangsow, J. Babbage, A. Taddei, C. Czupalla, M. Reis, A. Felici, H. Wolburg, M. Fruttiger, H. von Melchner, K.-H. Plate, H. Gerhardt, E. Dejana