Deciphering the heterogeneity of B-lymphoid subpopulations impacting on CNS recovery from acute multiple sclerosis bouts (A08*)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 408885537

B lymphocytes have been more recently recognized to possess a dual role in MS pathogenesis. On the one hand, B cells promote inflammation of the central nervous system and MS progression, while on the other hand, B-lymphoid inhibition of pathogenic T cell functions ameliorates MS severity and facilitates recovery from acute MS bouts. To understand the functional dichotomy, we aim at a comprehensive phenotyping of individual B cell subpopulations followed by their transcriptional profiling to better understand the molecular checkpoints of B cell specification.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 274: Checkpoints of Central Nervous System Recovery
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Professor Dr. Martin Weber; Professor Dr. Jürgen Wienands