Programming of transcriptional identity in response to oestrogens and androgens in developing human brain cells (M02)

• Subject Area: Cell Biology ; Endocrinology, Diabetology, Metabolism ; Developmental Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 515637292

The PIs will use human induced pluripotent stem cells (hiPSCs) as a model system to analyse sex chromosome and sex hormone action during early stages of human brain development as well as during GnRH+ neuronal differentiation in 46,XX, 46,XY and sex hormone receptor-deficient cells. Initially, they will use two hiPSCs derived from patients with complete androgen insensitivity (CAIS) generated for this project.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1665: Sexdiversity - Determinants, meanings and implications of sex diversity in sociocultural, medical and biological landscapes
• Applicant Institution: Universität zu Lübeck
• Project Heads: Privatdozentin Dr. Nadine Hornig; Dr. Franz-Josef Müller