Describing the metabolome of sex variability (M05)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Biochemistry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 515637292

This project will employ a metabolome analysis of the systems under investigation described in the other projects above and extracts, namely mouse serum and urine, cell supernatants, and human serum and urine. We will then apply metabolomics to discriminate between different entities and to define organisational and regulatory profiles. Identifying sex-related metabolic pathways by comparing samples from individuals with DSD with typical male and female persons and combining this with the metabolic analysis of mouse models of sex development will allow us to decipher metabolic changes affected by chromosomal sex and hormone status.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1665: Sexdiversity - Determinants, meanings and implications of sex diversity in sociocultural, medical and biological landscapes
• Applicant Institution: Universität zu Lübeck
• Project Head: Privatdozent Dr. Karsten Seeger