The atlas of steroid hormones in human genital tissues by simultaneous determination of the delta-5, alternative, backdoor and 11-oxygenated C-19 metabolites (M06)

• Subject Area: Endocrinology, Diabetology, Metabolism ; Biochemistry
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 515637292

This project will work with a combination, significant extension and validation of our existing LC-MS/MS methods for the simultaneous, sensitive and specific determination of defined steroid metabolites representing the classical, the alternative, the backdoor and the 11-oxygenated C19 androgen synthesis pathways. Second, the PIs plan to compare the androgenic steroidomes of different specific, molecularly defined (mutation-positive) forms of XY-DSD.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1665: Sexdiversity - Determinants, meanings and implications of sex diversity in sociocultural, medical and biological landscapes
• Applicant Institution: Universität zu Lübeck
• Project Heads: Professor Dr. Paul-Martin Holterhus; Alexandra Kulle