A genetic screen for new Polycomb group genes in Drosophila melanogaster and biochemical purification of novel PcG protein complexes

• Applicant: Dr. Jürg Müller
• Subject Area: General Genetics and Functional Genome Biology
• Term: from 2002 to 2009
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5370380

Final Report Abstract

No abstract available

Publications

• (2002). Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111,197-208
  Müller, J., Hart, C.M., Francis, N.J., Vargas, M.L., Sengupta, A., Wild, B., Miller, E.L., O'Connor, M.B., Kingston, R.E., and Simon, J.A.
  
• (2003). Molecular and genetic analysis of the Polycomb group gene Sex combs extra/Ring in Drosophila. Mech. Dev. 120, 949-954
  Fritsch, C, Beuchle, D. and Müller, J.
  
• (2006). A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine binding activities. Genes Dev 20, 1110-1122
  Klymenko, T., Papp, B., Fischle, W.. Köcher, T.. Schelder, M., Fritsch, C, Wild, B., Wilm, M. and Müller, J.
  
• (2007). A genetic screen identifies novel Polycomb group genes in Drosophila. Genetics 176, 2099-2108
  Gaytan de Ayala Alonso, A., Gutierrez, L., Fritsch, C., Papp, B., Beuchle, D. and Müller, J.
  
• (2007). Structural and functional analyses of methyllysine binding by the malignant brain tumour repeat protein Sex comb on midleg. EMBO Rep. 8, 1031-1037
  Grimm, C., Gaytan de Ayala Alonso, A., Rybin, V., Steuerwald, U., Ly-Hartig, N., Fischle, W., Müller, J. and Müller, C.W.
  
• (2009) Essential role of the glycosyltransferase Sxc/Ogt in Polycomb repression. Science 325, 93-96
  Gambetta, M.C., Oktaba, K. and Müller, J.
  
• (2010) Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature, May 13; 465(7295):243-7
  Scheuermann, J.C, Gaytán de Ayala Alonso, A., McGinty, R., Fraterman, S., Wilm, M., Muir, T. and Müller, J.