Haarwuchsstörungen durch Stress: Nachweis, pathophysiologische Grundlagen und neuropharmakologische Manipulation, GEM mit AR 232/14-2

• Antragsteller: Professor Dr. Ralf Paus
• Fachliche Zuordnung: Gynäkologie und Geburtshilfe
• Förderung: Förderung von 2002 bis 2008
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5374276

• Erstellungsjahr: 2008

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Inhibition of human hair follicle growth by endo-and exocannabinoids. FASEB J 2007 21:3534-41
  Telek A, Biró T, Bodó E, Toth BI, Borbíró I, Kunos G, Paus R
  
• Control of human hair growth by neurotrophins: brain-derived neurotrophic factor inhibits hair shaft elongation, induces catagen, and stimulates follicular transforming growth factor beta2 expression. J Invest Dermatol. 2005;124(4):675-85
  Peters EM, Hansen MG, Overall RW, Nakamura M, Pertile P, Klapp BF, Arck PC, Paus R
  
• Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition. J Mol Med. 2005;83(5):386-96
  Arck PC, Handjiski B, Kuhlmei A, Peters EM, Knackstedt M, Peter A, Hunt SP, Klapp BF, Paus R
  
• From the brain-skin connection: the neuroendocrine-immune misalliance of stress and itch. Neuroimmunomodulation. 2006;13(5-6):347-56
  Arck P, Paus R
  
• Frontiers in pruritus research: scratching the brain for more effective itch therapy. J Clin Invest 2006 116:1174-1185
  Paus R, Schmelz M, Biró T, Steinhoff M
  
• Hair growth inhibition by psychoemotional stress: a mouse model for neural mechanisms in hair growth control. Exp Dermatol. 2006; 15(1):1-13
  Peters EM, Arck PC, Paus R
  
• Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression. Am J Pathol. 2006 168(3):748-56
  Foitzik K, Krause K, Conrad F, Nakamura M, Funk W, Paus R
  
• Nerve growth factor and its precursor differentially regulate hair cycle progression in mice. J Histochem Cytochem. 2006;54(3):275-88
  Peters EM, Hendrix S, Gölz G, Klapp BF, Arck PC, Paus R
  
• Neuroimmunoendocrine circuitry of the 'brain-skin connection'. Trends Immunol. 2006;27(1):32-9
  Paus R, Theoharides TC, Arck PC
  
• Neuroimmunology of stress: skin takes center stage. J Invest Dermatol. 2006 ;126(8):1697-704
  Arck PC, Slominski A, Theoharides TC, Peters EM, Paus R
  
• p75 Neurotrophin Receptor-Mediated Signaling Promotes Human Hair Follicle Regression (Catagen). Am J Pathol. 2006;168(1):221-34
  Peters EM, Stieglitz MG, Liezman C, Overall RW, Nakamura M, Hagen E, Klapp BF, Arck P, Paus R
  
• El estrés y la piel. Cap. 8 in: Estrés y nuevas perspectivas en psicopatología y salud (Albalustri A ed.), pp.223-266, Editorial Cientifica Interamericana, Buenos Aires, 2007
  Label M, Paus R, Arck P, Richardson S, Woscoff A, Tausk F
  
• Frontiers in the (neuro-)endocrine controls of hair growth. J Invest Dermatol Symp Proc. 2007 12:20-2
  Paus R
  
• Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest. 2007 117(8):2019-27
  Gilhar A, Paus R, Kalish RS
  
• Neuronal plasticity of the "brain-skin connection": stress-triggered upregulation of neuropeptides in dorsal root ganglia and skin via nerve growth factordependent pathways. J Mol Med. 2007;85(12):1369-78
  Joachim RA, Kuhlmei A, Dinh QT, Handjiski B, Fischer T, Peters EM, Klapp BF, Paus R, Arck PC
  
• Probing the effects of stress mediators on the human hair follicle: substance P holds central position. Am J Pathol. 2007;171(6):1872-86
  Peters EM, Liotiri S, Bodó E, Hagen E, Bíró T, Arck PC, Paus R
  
• Neuro-endocrinology of epithelial hair follicle stem cells. Mol Cell Endocrinol
  Paus R, Arck P, Tiede S
  
• The alchemy of immune privilege explored from a neuroimmunological perspective, Current Opin Pharmacol Immunomod.
  Arck P, Gilhar A, Paus R