Identification and characterization of Shinga toxin-independent virulence factors of enterohemorrhagic Escherichia coli which contribute to vascular endothelium injury

• Applicant: Professor Dr. Helge Karch
• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: from 2002 to 2010
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5390014

• Final Report Year: 2010

Final Report Abstract

No abstract available

Publications

• 2004. Characterization of cytolethal distending toxin genes and expression in Shiga toxin-producing Escherichia coli strains of non-0157 serogroups. Infect. Immun. 72:1812- 1816
  Bielaszewska, M., M. Fell, L. Greune, R. Prager, A. Fruth, H. Tschäpe, M. A. Schmidt, H. Karch
  
• 2005. Consequences of enterohaemorrhagic Escherichia coli infection for the vascular endothelium. Thromb. Haemost. 94:312-318
  Bielaszewska, M., H, Karch
  
• 2005. Effects of the cytolethal distending toxin from enterohemorrhagic Escherichia coli 0157:H on human endothelial cells. Infect. Immun. 73:552-562
  Bielaszewska, M., B. Sinha, B. Hasslinger, T. Kuczius, H. Karch
  
• 2005. Enterohaemorrhagic Escherichia coli in human medicine. Int. J. Med. Microbiol. 295:405-418
  Karch, H., P.I. Tarr, M. Bielaszewska
  
• 2006. Cytolethal distending toxin in Escherichia coli 0157:H7: Spectrum of conservation, structure, and endothelial toxicity. J. Clin. Microbiol. 44: 1844-1846
  Friedrich, A. W., S. Lu, M. Bielaszewska, R. Prager, P. Bruns, J.-G. Xu, H. Tschäpe, H. Karch
  
• 2006. New aspects in the pathogenesis of enteropathic hemolytic uremic syndrome. Semin. Thromb. Hemost. 32:105-112
  Karch, H., A, W. Friedrich, A. Gerber, L. B. Zimmerhackl, M. A. Schmidt, M. Bielaszewska
  
• 2007. Enterohaemorrhagic Escherichia coli 026:H11/H-: a human pathogen in emergence. Berl. Munch. Tierarztl. Wochenschr. 120:279-287
  Bielaszewska, M., W. Zhang, A. Mellmann, H. Karch
  
• 2007. Hemolysin from Shiga toxin-negative Escherichia coli 026 strains injures microvascular endothelium. Microbes Infect. 9:282-290
  ldick, T., M. Bielaszewska, W. Zhang, J. Brockmeyer, H. Schmidt, A.W. Friedrich, K.S. Kim, M.A. Schmidt, H. Karch
  
• 2008. Glycosphingolipids in vascular endothelial cells: relationship of heterogeneity in Gb3Cer/CD77 receptor expression with differential Shiga toxin 1 cytotoxicity. Glycoconj. J. 25:291-304
  Schweppe, C.H., M. Bielaszewska, G. Pohlentz, A.W. Friedrich, H. Büntemeyer, M.A. Schmidt, K.S. Kim, J. Peter-Katalinic, H. Karch, J. Müthing
  
• 2009. Shiga toxin, cytolethal distending toxin, and hemolysin repertoires in clinical Escherichia coli 091 isolates. J. Clin. Microbiol. 47:2061-2066
  Bielaszewska, M., F, Stoewe, A. Fruth, W. Zhang, R. Prager, J. Brockmeyer, A. Mellmann, H. Karch, A.W. Friedrich
  
• 2009. Shiga toxins, glycosphmgolipid diversity, and endothelial cell injury. Thromb. Haemost. 101:252-264
  Müthing, J., CH. Schweppe, H. Karch, A.W. Friedrich
  
• 2009. Vacuolisation of human microvascular endothelial cells by enterohaemorrhagic Escherichia coli. Thromb. Haemost. 102:1080-1092
  Bielaszewska, M., A. Bauwens, L. Greune, B. Kemper, U. Dobrindt, J.M. Geelen, K.S. Kim, M.A. Schmidt, H, Karch
  
• 2009. Vesicular stabilization and activity augmentation of enterohaemorrhagic Escherichia coli haemolysin. Mol. Microbiol. 71:1496-1508
  Aldick, T., M. Bielaszewska, B.E. Uhlin, H.-U. Humpf, S.N. Wai, H. Karch