Analysis of the HIF-1 activation upon infection with Bartonella henselae and other pathogens

• Applicant: Professor Dr. Volkhard A. J. Kempf
• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: from 2002 to 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5390246

• Final Report Year: 2010

Final Report Abstract

No abstract available

Publications

• Activation of hypoxia inducible factor-1 in bacillary angiomatosis: evidence for a role of HIF-1α in bacterial infections. Circulation 2005, 111(8):1052-1062
  Kempf, V.A.J., Lebiedziejewski, M., Alitalo, K., Wälzlein, J, Ehehalt, U., Fiebig, J., Huber, S., Schutt, B., Sander, CA., Müller, S., Grassl, G.A., Brehm, B., Yazdi, A.S., Autenrieth, I.B.
  
• Induktion von Blutgefäßwachstum: Eine einzigartige Eigenschaft von Barionella henselae. Biospektrum 2006 12(l):33-4
  Eberhardt, C., Hartmann, H., Kempf, V.A.J.
  
• Mechanisms of Disease-Acute Oxygen Sensing Mechanisms (Letter). N Eng J Med 2006, 2;354(9):975-7
  Eltzschig, H., Karhausen, J., Kempf, V.A.J.
  
• Hypoxia-independent activation of HIF-1 by Enterohacteriaceae and their siderophores. Gastroenterology. 2008, 134(3):756-67
  Hartmann, H., Eltzschig, H., Würz, H., Hantke, K., Rakin, A., Yazdi, A.S., Matteoli, G., Bohn, E., Autenrieth, I.B., Karhausen, J., Neumann, D., Colgan, S.P., Kempf, V.A.J.
  
• Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during respiratory syncytial virus infection. PloS one 2008, 7;3(10):e3352
  Haeberie, H., Dürrstein, C., Rosenberger, P., Kuhlicke, J., Kempf, V.A.J., Garofalo, R.P., Eltzschig, H.K.
  
• Use of Bartonella adhesin A (BadA) immunoblotting in the serodiagnosis of Bartonella henselae infections. Int J Med Microbiol 2008 298(7-8):579-90
  Wagner, CL., Riess, T., Linke, D., Eberhardt, C, Schäfer, A., Reutter, S., Kempf, V.A.J.
  
• Proteomic analysis of the bacterial pathogen Bartonella henselae and identification of immunogenic proteins for serodiagnosis. Proteomics 2009, 30;9(7): 1967-1981
  Eberhardt, C., S. Engelmann, H. Kusch, D. Albrecht, M. Hecker, I.B. Autenrieth and V. A. J. Kempf