Biokatalysatoren für die Synthese komplexer Cyclopeptide

• Applicant: Professor Dr. Mohamed A. Marahiel
• Subject Area: Biochemistry
• Term: from 2003 to 2010
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5469960

Final Report Abstract

No abstract available

Publications

• (2006) Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145. Biochemistry 45: 10474-10481
  Kopp, F., Grünewald, J., Mahlert, C. and Marahiel, M. A.
  
• (2006) Peptide macrocyclization: the reductase of the nostocyclopeptide synthetase triggers the self-assembly of a macrocyclic imine. J. Am. Chem. Soc. 128: 16478-16479
  Kopp, F., Mahlert, C., Grünewald, J., Marahiel, M.A.
  
• (2006) Rational design of bacitracin A derivatives by incorporating natural product derived heterocycles. J. Am. Chem. Soc. 128: 10513-10520
  Wagner, B., Schumann, D., Linne, U., Koert, U. and Marahiel, M. A.
  
• (2006) Solvent engineering substantially enhances the chemoenzymatic production of surfactin. Chembiochem 7: 595-597
  Wagner, B., Sieber, S. A., Baumann, M. and Marahiel, M. A.
  
• (2006) The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a nonribosomal lipopeptide. J. Mol. Biol. 359: 876-889
  Samel, S.A., Wagner, B., Marahiel, M. A. and Essen, L. O.
  
• (2007) Where chemistry meets biology: the chemoenzymatiac synthesis of nonribosomal peptides and polyketides. Curr. Op. Biotechnol. 18: 513-520
  Kopp, D. and Marahiel, M.A.
  
• (2007). The iterative gramicidin s thioesterase catalyzes peptide ligation and cyclization. Chem. Biol. 14: 13-22
  Hoyer, K.M., Mahlert, C., Marahiel, M.A.
  
• (2008) How to tailor non-ribosomal peptide products - new clues about the structures and mechaisms of modifying enzymes. Mol. Biosyst. 4: 387-393
  Samel, S.A., Marahiel, M.A. and Essen, L.O.