Project Details
Projekt
Biokatalysatoren für die Synthese komplexer Cyclopeptide
Applicant
Professor Dr. Mohamed A. Marahiel
Subject Area
Biochemistry
Term
from 2003 to 2010
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5469960
Final Report Year
2014
No abstract available
Publications
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(2006) Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145. Biochemistry 45: 10474-10481
Kopp, Florian; Grünewald, Jan; Mahlert, Christoph & Marahiel, Mohamed A.
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(2006) Peptide macrocyclization: the reductase of the nostocyclopeptide synthetase triggers the self-assembly of a macrocyclic imine. J. Am. Chem. Soc. 128: 16478-16479
Kopp, Florian; Mahlert, Christoph; Grünewald, Jan & Marahiel, Mohamed A.
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(2006) Rational design of bacitracin A derivatives by incorporating natural product derived heterocycles. J. Am. Chem. Soc. 128: 10513-10520
Wagner, Björn; Schumann, Dirk; Linne, Uwe; Koert, Ulrich & Marahiel, Mohamed A.
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(2006) Solvent engineering substantially enhances the chemoenzymatic production of surfactin. Chembiochem 7: 595-597
Wagner, Björn; Sieber, Stephan A.; Baumann, Marcus & Marahiel, Mohamed A.
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(2006) The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a nonribosomal lipopeptide. J. Mol. Biol. 359: 876-889
Samel, Stefan A.; Wagner, Björn; Marahiel, Mohamed A. & Essen, Lars-Oliver
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(2007) Where chemistry meets biology: the chemoenzymatiac synthesis of nonribosomal peptides and polyketides. Curr. Op. Biotechnol. 18: 513-520
Kopp, Florian & Marahiel, Mohamed A.
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(2007). The iterative gramicidin s thioesterase catalyzes peptide ligation and cyclization. Chem. Biol. 14: 13-22
Hoyer, Katharina M.; Mahlert, Christoph & Marahiel, Mohamed A.
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(2008) How to tailor non-ribosomal peptide products - new clues about the structures and mechaisms of modifying enzymes. Mol. Biosyst. 4: 387-393
Samel, Stefan A.; Marahiel, Mohamed A. & Essen, Lars-Oliver
