Die Rolle der endothelialen und induzierbaren Stickoxid-Synthetase (eNOS und iNOS) bei der Vermittlung des hepatischen Schadens nach Lebertransplantation

• Antragsteller: Dr. Lars Oliver Conzelmann
• Fachliche Zuordnung: Allgemein- und Viszeralchirurgie
• Förderung: Förderung von 2003 bis 2010
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5400322

• Erstellungsjahr: 2011

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Orthotopic liver transplantation in knockout mice: Is TNFa involved in early graft injury and regeneration? Transplantation Proceedings Vol. 34. 2002, Issue 6, pp. 2299–2300.
  Conzelmann LO, Schemmer P, Zhong Z, Smutney OM, Bunzendahl H, Thurman RG.
  (Siehe online unter https://dx.doi.org/10.1016/S0041-1345(02)03243-8)
• Prevenfion of hepafic ischemia-reperfusion injury by green tea extract. American Joumal of Physiology, Vol. 283. 2002, Issue 4: G957-964.
  Zhong Z, Froh M, Conner HD, Li X, Conzelmann LO, Mason RP, Thurman RG.
  (Siehe online unter https://dx.doi.org/10.1152/ajpgi.00216.2001)
• Dependence of liver injury after hemorrhage / resuscitation in mice on NADPH oxidase-derived superoxide. Shock, Vol. 19. 2003, Issue 4, pp 345-351.
  Lehnert M, Arteel GE, Smutney OM, Conzelmann LO, Zhong Z, Thurman RG, Lemasters JJ.
  
• Impaired Ras membrane-associafion and activation in PPAR knockout mice following partial hepatectomy. American Journal of Physiology, Vol. 284. 2003, Issue 2: G302-12.
  Wheeler M.D., Smutney O.M., Check J.F., Conzelmann L.O., Rusyn I, Schulte-Hermann R, Thurman R.G.
  (Siehe online unter https://dx.doi.org/10.1152/ajpgi.00175.2002)
• Reduced-size liver transplantafion in the mouse. Transplantation, Vol. 76. 2003, Issue 3, pp 496-501.
  Conzelmann L.O., Zhong Z, Bunzendahl H, Wheeler M.D., Lemasters J.J.
  
• TNF alpha -Induced Ras Activafion Due to Ethanol Promotes Hepatocyte Proliferafion Independently of Liver Injury in the Mouse. Hepatology, Vol. 39. 2004, Issue 3, pp. 721–731.
  Isayama F., Froh M., Yin M., Conzelmann L.O., Milton R.J., McKim S.E., Wheeler M.D.
  (Siehe online unter https://dx.doi.org/10.1002/hep.20137)
• Graft tumor necrosis factor receptor-1 protects after mouse liver Transplantation whereas host tumor necrosis factor receptor-l promotes injury. Transplantation, Vol. 82. 2006, Issue 9, pp 1214-1220.
  Conzelmann L.O., Lehnert M., Kremer M., Zhong Z., Wheeler M.D., Lemasters J.J.
  (Siehe online unter https://dx.doi.org/10.1097/01.tp.0000239190.95190.5e)
• Extrahepatic cells contribute to the progenitor/stem cell response following reduced-size liver transplantation in mice. Experimental Biology and Medicine, Vol. 232. 2007, Issue 4, pp. 571-580.
  Conzelmann L.O., Hines I.N., Kremer M, Perry A.W., Lemasters J.J., Wheeler M.D.
  
• Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats. World Journal of Gastroenterology, Vol. 13. 2007, Issue 25, pp. 3478-3486.
  Froh M., Conzelmann L.O., Walbrun P., Netter S., Wiest R., Wheeler M.D., Lehnert M., Uesugi T., Scholmerich J., Thurman R.G.
  
• Dietary glycine blunts liver injury after bile duct ligation in rats. World Journal of Gastroenterology, Vol. 14. 2008, Issue 39, pp. 5996-6003.
  Froh M., Zhong Z., Walbrun P., Lehnert M., Netter S., Wiest R., Conzelmann L., Gabele E., Hellerbrand C., Schölmerich J., Thurman R.G.
  (Siehe online unter https://dx.doi.org/10.3748/wjg.14.5996)
• Differential effects of GdCl3- or MDP treatment on rat liver microcirculation and gene expression in the hepatic non-parenchymal cell fraction in LPS shock. Microcirculation, Vol. 15. 2008, Issue 5, pages 427–439.
  Henrich D., Lehnert M., Herzog C., Niederlaender S., Relja B., Conzelmann L., Marzi I.
  (Siehe online unter https://dx.doi.org/10.1080/10739680701675213)
• The adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospecfive, randomised laboratory investigation. Critical Care, Vol. 12. 2008, Issue 5: R125.
  Kayhan N., Funke B., Conzelmann L.O., Winkler H., Hofer S., Steppan J., Schmidt H., Bardenheuer H., Vahl C.F., Weigand M.A.
  (Siehe online unter https://dx.doi.org/10.1186/cc7033)
• Deutsches Register für akute Aortendissektion Typ A (GERAADA). Zeitschrift für Herz-, Thorax- und Gefäßchirurgie, Vol. 23. 2009, Issue 5, pp. 298-304.
  Conzelmann L.O., Dapunt O., Kallenbach K., Karck M., Weigang E.
  (Siehe online unter https://dx.doi.org/10.1007/s00398-009-0733-x)
• Reevaluation of Direct True Lumen Cannulation in Surgery for Acute Type A Aortic Dissecfion. The Annals of Thoracic Surgery, Vol. 87. 2009, Issue 4, pp. 1182–1186.
  Conzelmann L.O., Kayhan N., Mehlhorn U., Weigang E., Dahm M., Vahl C.F.
  (Siehe online unter https://dx.doi.org/10.1016/j.athoracsur.2009.01.027)
• Reevaluation of two techniques of harvesfing the skeletonized internal mammary artery. The Thoracic and Cardiovascular Surgeon, Vol. 57. 2009, Issue 4, pp. 214-216.
  Peivandi A.A., Weigang E., Kayhan N., Hakami L., Ister D., Denk K., Conzelmann L., Vahl C.F.
  (Siehe online unter https://dx.doi.org/10.1055/s-2008-1039272)
• German registry for acute aortic dissection type A(GERAADA)- lessons learned from the registry. The Thoracic and Cardiovascular Surgeon, Vol. 58. 2010, Issue 3, pp. 154-158.
  Weigang E, Conzelmann LO, Kallenbach K, Dapunt 0, Karck M.
  (Siehe online unter https://dx.doi.org/10.1055/s-0029-1240806)
• True-Lumen Collapse of the Ascending Aorta in Acute Type A Aortic Dissection. European Journal Cardio-Thoracic Surgery, Vol. 37. 2010, Issue 4, Pp. 955. The Thoracic and Cardiovascular Surgeon, Ausgabe S 01, Volume 58. 2010, MP 42.
  Conzelmann L.O., Weigang E., Kreitner K.F., Vahl C.F.
  (Siehe online unter https://dx.doi.org/10.1055/s-0029-1246750)
• Value and pitfalls of neurophysiological Monitoring in thoracic and thoracoabdominal aortic replacement and endovascular repair. The Thoracic and Cardiovascular Surgeon, Vol. 58. 2010, Issue 5, pp. 260-264.
  ter Wolbeek C, Hartert M, Conzelmann LO, Peivandi AA, Czemy M, Gottardi R, Beyersdorf F, Weigang E.
  (Siehe online unter https://dx.doi.org/10.1055/s-0030-1249904)
• Giant bronchogenic cyst within the aortic wall mimicking symptoms of acute type A aortic dissection. The Journal of Thoracic and Cardiovascular Surgery, Vol. 141. 2011, Issue 1, pp. e7–e8.
  Senbaklavaci O, Conzelmann LO, Brochhausen C, Vahl CF.
  (Siehe online unter https://dx.doi.org/10.1016/j.jtcvs.2010.09.031)
• Successful Management of Fulminant Pulmonary Embolism Using a Novel Portable Extracorporeal Life Support System. The Annals of Thoracic Surgery, Vol. 91. 2011, Issue 4, pp. 1265–1267.
  Conzelmann LO, Mehlhorn U, Weigang E, Kayhan N, Vahl CF.
  (Siehe online unter https://dx.doi.org/10.1016/j.athoracsur.2010.09.045)