Die Rolle der endothelialen und induzierbaren Stickoxid-Synthetase (eNOS und iNOS) bei der Vermittlung des hepatischen Schadens nach Lebertransplantation

• Antragsteller: Dr. Lars Oliver Conzelmann
• Fachliche Zuordnung: Allgemein- und Viszeralchirurgie
• Förderung: Förderung von 2003 bis 2010
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5400322

• Erstellungsjahr: 2011

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Orthotopic liver transplantation in knockout mice: Is TNFa involved in early graft injury and regeneration? Transplantation Proceedings Vol. 34. 2002, Issue 6, pp. 2299–2300.
  Conzelmann, L.O; Schemmer, P; Zhong, Z; Smutney, O.M; Bunzendahl, H & Thurman, R.G
  
• Prevenfion of hepafic ischemia-reperfusion injury by green tea extract. American Joumal of Physiology, Vol. 283. 2002, Issue 4: G957-964.
  Zhong, Zhi; Froh, Matthias; Connor, Henry D.; Li, Xiangli; Conzelmann, Lars O.; Mason, Ronald P.; Lemasters, John J. & Thurman, Ronald G.
  
• Dependence of liver injury after hemorrhage / resuscitation in mice on NADPH oxidase-derived superoxide. Shock, Vol. 19. 2003, Issue 4, pp 345-351.
  Lehnert M, Arteel GE, Smutney OM, Conzelmann LO, Zhong Z, Thurman RG, Lemasters JJ.
  
• Impaired Ras membrane-associafion and activation in PPAR knockout mice following partial hepatectomy. American Journal of Physiology, Vol. 284. 2003, Issue 2: G302-12.
  Wheeler, Michael D.; Smutney, Olivia M.; Check, Jennifer F.; Rusyn, Ivan; Schulte-Hermann, R. & Thurman, Ronald G.
  
• Reduced-size liver transplantafion in the mouse. Transplantation, Vol. 76. 2003, Issue 3, pp 496-501.
  Conzelmann L.O., Zhong Z, Bunzendahl H, Wheeler M.D., Lemasters J.J.
  
• TNF alpha -Induced Ras Activafion Due to Ethanol Promotes Hepatocyte Proliferafion Independently of Liver Injury in the Mouse. Hepatology, Vol. 39. 2004, Issue 3, pp. 721–731.
  Isayama, Fuyumi; Froh, Matthias; Yin, Ming; Conzelmann, Lars O.; Milton, Richard J.; McKim, Stephen E. & Wheeler, Michael D.
  
• Graft tumor necrosis factor receptor-1 protects after mouse liver Transplantation whereas host tumor necrosis factor receptor-l promotes injury. Transplantation, Vol. 82. 2006, Issue 9, pp 1214-1220.
  Conzelmann, Lars O.; Lehnert, Mark; Kremer, Michael; Zhong, Zhi; Wheeler, Michael D. & Lemasters, John J.
  
• Extrahepatic cells contribute to the progenitor/stem cell response following reduced-size liver transplantation in mice. Experimental Biology and Medicine, Vol. 232. 2007, Issue 4, pp. 571-580.
  Conzelmann L.O., Hines I.N., Kremer M, Perry A.W., Lemasters J.J., Wheeler M.D.
  
• Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats. World Journal of Gastroenterology, Vol. 13. 2007, Issue 25, pp. 3478-3486.
  Froh M., Conzelmann L.O., Walbrun P., Netter S., Wiest R., Wheeler M.D., Lehnert M., Uesugi T., Scholmerich J., Thurman R.G.
  
• Dietary glycine blunts liver injury after bile duct ligation in rats. World Journal of Gastroenterology, Vol. 14. 2008, Issue 39, pp. 5996-6003.
  Froh, Matthias; Zhong, Zhi; Walbrun, Peter; Lehnert, Mark; Netter, Susanne; Wiest, Reiner; Conzelmann, Lars; Gäbele, Erwin; Hellerbrand, Claus; Schölmerich, Jürgen & Thurman, Ronald G.
  
• Differential effects of GdCl3- or MDP treatment on rat liver microcirculation and gene expression in the hepatic non-parenchymal cell fraction in LPS shock. Microcirculation, Vol. 15. 2008, Issue 5, pages 427–439.
  Henrich, Dirk; Lehnert, Mark; Herzog, Carsten; Niederlaender, Stephan; Relja, Borna; Conzelmann, Lars & Marzi, Ingo
  
• The adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospecfive, randomised laboratory investigation. Critical Care, Vol. 12. 2008, Issue 5: R125.
  Kayhan, Nalan; Funke, Benjamin; Conzelmann, Lars Oliver; Winkler, Harald; Hofer, Stefan; Steppan, Jochen; Schmidt, Heinfried; Bardenheuer, Hubert; Vahl, Christian-Friedrich & Weigand, Markus A.
  
• Deutsches Register für akute Aortendissektion Typ A (GERAADA). Zeitschrift für Herz-, Thorax- und Gefäßchirurgie, Vol. 23. 2009, Issue 5, pp. 298-304.
  Conzelmann, L.O.; Dapunt, O.; Kallenbach, K.; Karck, M. & Weigang, E.
  
• Reevaluation of Direct True Lumen Cannulation in Surgery for Acute Type A Aortic Dissecfion. The Annals of Thoracic Surgery, Vol. 87. 2009, Issue 4, pp. 1182–1186.
  Conzelmann, Lars O.; Kayhan, Nalan; Mehlhorn, Uwe; Weigang, Ernst; Dahm, Manfred & Vahl, Christian F.
  
• Reevaluation of two techniques of harvesfing the skeletonized internal mammary artery. The Thoracic and Cardiovascular Surgeon, Vol. 57. 2009, Issue 4, pp. 214-216.
  Peivandi, A.; Weigang, E.; Kayhan, N.; Hakami, L.; Ister, D.; Denk, K.; Conzelmann, L. & Vahl, C.
  
• German registry for acute aortic dissection type A(GERAADA)- lessons learned from the registry. The Thoracic and Cardiovascular Surgeon, Vol. 58. 2010, Issue 3, pp. 154-158.
  Weigang, E.; Conzelmann, L.; Kallenbach, K.; Dapunt, O. & Karck, M.
  
• True-Lumen Collapse of the Ascending Aorta in Acute Type A Aortic Dissection. European Journal Cardio-Thoracic Surgery, Vol. 37. 2010, Issue 4, Pp. 955. The Thoracic and Cardiovascular Surgeon, Ausgabe S 01, Volume 58. 2010, MP 42.
  Conzelmann, LO; Kayhan, N; Mehlhorn, U; Weigang, E & Vahl, CF
  
• Value and pitfalls of neurophysiological Monitoring in thoracic and thoracoabdominal aortic replacement and endovascular repair. The Thoracic and Cardiovascular Surgeon, Vol. 58. 2010, Issue 5, pp. 260-264.
  ter Wolbeek, C.; Hartert, M.; Conzelmann, L.; Peivandi, A.; Czerny, M.; Gottardi, R.; Beyersdorf, F. & Weigang, E.
  
• Giant bronchogenic cyst within the aortic wall mimicking symptoms of acute type A aortic dissection. The Journal of Thoracic and Cardiovascular Surgery, Vol. 141. 2011, Issue 1, pp. e7–e8.
  Senbaklavaci, Ömer; Conzelmann, Lars Oliver; Brochhausen, Christoph & Vahl, Christian F.
  
• Successful Management of Fulminant Pulmonary Embolism Using a Novel Portable Extracorporeal Life Support System. The Annals of Thoracic Surgery, Vol. 91. 2011, Issue 4, pp. 1265–1267.
  Conzelmann, Lars O.; Mehlhorn, Uwe; Weigang, Ernst; Kayhan, Nalan & Vahl, Christian F.