Recognition of DNA by Modified Peptide Nucleic Acids (PNA) for Gene Targeting and Analysis

• Applicant: Professor Dr. Wolfgang Knoll
• Subject Area: Preparatory and Physical Chemistry of Polymers
• Term: from 2004 to 2010
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5408185

• Final Report Year: 2010

Final Report Abstract

No abstract available

Publications

• Comparison of Surface Plasmon Resonance Spectroscopy and Quartz Crystal Microbalance Techniques for Studying DNA Assembly and Hybridization. iosensors & Bioelectronics, 21, 719-726 (2005)
  Su, X.; Wu, Y.J.; Knoll, W.
  
• DNA Hybridization on Plasma-Polymerized Allylamine. Macromolecules, 38, 1271-1276 (2005)
  Zhang, Z.; Knoll, W.; Foerch, R.; Holcomb, R.; Roitman, D.
  
• In Situ Hybridization of PNA/DNA Studied Label-Free by Electrochemical Impedance Spectroscopy. Chem. Comm., 23, 2969-2971 (2005)
  Liu, J.; Tian, S.; Nielsen, P.; Knoll, W.
  
• Simultaneously Amplified Electrochemcial and Surface Plasmon Optical Detection of DNA Hybridization Based on Ferrocene-Streptavidin Conjugates. Anal. Chem., 77, 2756-2761 (2005)
  Liu, J.; Tian, S.; Tiefenauer, L.; Nielsen, P.; Knoll, W.
  
• Surface Density Dependence of PCR Amplicon Product Hybridization on PNA/DNA Probe Layers. Biophys. J., 88, 2745-2751 (2005)
  Yao, D.; Kim, J.; Nielsen, P.; Sinner, E.; Knoll, W.
  
• Kinetic and Affinity Analysis of Hybridization Reactions Between PNA Probes and Oligonucleotides and Genetically Modified DNA Targets Using Surface Plasmon Field-Enhanced Fluorescence Spectroscopy (SPFS). Biointerphases, 1, 113-122 (2006)
  Park, H.; Germini, A.; Sforza, S.; Corradini, R.; Marchelli, R.; Knoll, W.
  
• PNA-DNA Hybridization Study Using Labeled-Streptavidin by Voltammetry and Surface Plasmon Fluorescence Spectroscopy. Anal. Chem., 78, 470-476 (2006)
  Liu, J.; Tian, S.; Tiefenauer, L.; Nielsen, P.; Knoll, W.
  
• Evaluation of Two- and Three-Dimensional Streptavidin Binding Platforms for Surface Plasmon Resonance Spectroscopy Studies of DNA Hybridization and Protein-DNA Binding. Biosensors & Bioelectronics, 22, 2700-2706 (2007)
  Yang, N.; Su, X.; Tjong, V.; Knoll, W.
  
• Surface Plasmon Enhanced Fluorescence Spectroscopy for DNA Detection Using Fluorescently Labelled PNA as "DNA Indicator". Angew.Chem., 119, 1-5 (2007)
  Chu, L.Q.; Förch, R.; Knoll, W.
  
• Comparison of Diferent Supromolecular Architectures for Oligonucleotide Biosensing. Langmuir, 24, 13001-13006 (2008)
  Mir, M.; Alvarez, M.; Azzaroni, O.; et al.
  
• Effect of ionic strength on PNA-DNA hybridization on surfaces and in solution. Biointerphases, 2, 80-88 (2008)
  Park, H.; Germini, A.; Sforza, S.; et al.
  
• Electrostatic Repulsion and Steric Hindrance Effects of Surface Probe Density on Deoxyribonucleic Acid (DNA)/Peptide Nucleic Acid (PNA) Hybridization. Thin Solid Films, 516, 8634-8639 (2008)
  Xu, F.; Pellino, A.M.; Knoll, W.
  
• Functional quantum-dot/dendrimer nanotubes for sensitive detection of DNA hybridization. Small, 4, 566-571 (2008)
  Feng, C.L.; Zhong, X.H.; Steinhart, M.; et al.
  
• Molecular architectures for electrocatalytic amplification of oligonucleotide hybridization. Analytical Chemistry, 80, 6554-6559 (2008)
  Mir, M.; Alvarez, M.; Azzaroni, O.; et al.
  
• Plasma Polymerized Epoxide Functional Surfaces for DNA Probe Immobilization. Biosensors & Bioelectronics, 24, 118-122 (2008)
  Chu, L.Q.; Förch, R.; Knoll, W.
  
• Surface Plasmon Fluorescence Techniques for Bio-Affinity Studies. Handbook of Surface Plasmon Resonance, Eds. R.B.M. Schasfoort and Anna J. Tudos Chpt. 9, 275-312 (2008)
  Knoll, W.; Kasry, A.; Liu, J.; Neumann, T.; Niu, L.; Park, H.; Robelek, R.; Yu, F.
  
• Effects of molecular orientation of fluorescently-labeled duplex DNA on emission anisotropy. Biosensors & Bioelectronics, 24, 1783-1787 (2009)
  Sato, A.; Menges, B.; Knoll, W.
  
• Quantum-Dot/Dendrimer Based Functional Nanotubes for Sensitive Detection of DNA-Hybridization. Smart Optics – Advanced in Science and Technology 55, 84-90 (2009)
  Feng, C.L.; Yu, Y.M.; Zhong, X.H.; et al.
  
• The importance of the photonic mode density in bioassays based on evanescent optical waves. Journal of Applied Physics, 105, Article Number 014701 (2009)
  Sato, A.; Menges, B.; Knoll, W.