Functional characterization of Borna disease virus replication and persistence using recombinant viruses: Molecular analyses of the regulatory and anti-apoptotic activities of the accessory protein X.

• Applicant: Professor Dr. Peter Stäheli, from 11/2010 until 10/2012
• Subject Area: Virology
• Term: from 2003 to 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5416657

• Final Report Year: 2005

Final Report Abstract

No abstract available

Publications

• 2006. RNA Polymerase II-Controlled Expression of Antigenomic RNA Enhances the Rescue Efficacies of Two Different Members of the Mononegavirales Independently of the Site of Viral Genome Replication. J Virol 80:5708-15
  Martin, A., P. Staeheli, and U. Schneider
  
• 2007. A Borna disease virus vector for expression of foreign genes in neurons of rodents. J Virol 81:7293-6
  Schneider, U., A. Ackermann, and P. Staeheli
  
• 2007. Functional characterization of the major and minor phosphorylation sites of the P protein of Borna disease virus. J Virol 81:5497-507
  Schmid, S., D. Mayer, U. Schneider, and M. Schwemmle
  
• 2007. Pathogenic potential of borna disease virus lacking the immunodominant CD8 T-cell epitope. J Virol 81:11187-94
  Richter, K., K. Baur, A. Ackermann, U. Schneider, J. Hausmann, and P. Staeheli
  
• 2007. The X protein of borna disease virus serves essential functions in the viral multiplication cycle. J Virol 81:7297-9
  Poenisch, M., S. Wille, A. Ackermann, P. Staeheli, and U. Schneider
  
• 2008. Polymerase read-through at the first transcription termination site contributes to regulation of Borna disease virus gene expression. J Virol 82:9537-45
  Poenisch, M., S. Wille, P. Staeheli, and U. Schneider
  
• 2008. Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction. PLoS ONE 3:e2032
  Habjan, M., I. Andersson, J. Klingstrom, M. Schumann, A. Martin, P. Zimmermann, V. Wagner, A. Pichlmair, U. Schneider, E. Muhlberger, A. Mirazimi, and F. Weber
  
• 2008. Viral accessory protein X stimulates the assembly of functional Borna disease virus polymerase complexes. J Gen Virol 89:1442-5
  Poenisch, M., P. Staeheli, and U. Schneider
  
• 2009. Protein X of Borna disease virus inhibits apoptosis and promotes viral persistence in the CNS of newborninfected rats. J Virol published ahead of print on 11 February 2009
  Poenisch, M., N. Burger, P. Staeheli, G. Bauer, and U. Schneider
  (See online at https://doi.org/10.1128/JVI.02284-08)