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Projekt Druckansicht

Biochemie

Antragsteller Dr. Kirill Alexandrov
Fachliche Zuordnung Biochemie
Förderung Förderung von 2004 bis 2008
Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5419295
 
Erstellungsjahr 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

  • Construction and analysis of Leishmania tarentolae transgenic strains free of selection markers. Mol Biochem Parasitol. 2007 155(2):71-83
    Mureev S, Kushnir S, Kolesnikov A, Breitling R, Alexandrov K
  • Synthesis of a fluorescent analogue of geranylgeranyl pyprophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase. Nature Protocols (2007) 2(11):2704-11
    Wu Y., Alexandrov K and Brunsveld L
  • "Inject-mix-react-separate-and-quantitate" (IMReSQ) method for screening enzyme inhibitors. J Am Chem Soc. 2008 Sep 10;130(36):11862-3
    Wong E, Okhonin V, Berezovski MV, Nozaki T, Waldmann H, Alexandrov K, Krylov SN
  • Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Angew Chem Int Ed Engl. 2008;47(20):3747-50
    Guo Z, Wu YW, Tan KT, Bon RS, Guiu-Rozas E, Delon C, Nguyen TU, Wetzel S, Arndt S, Goody RS, Blankenfeldt W, Alexandrov K, Waldmann H
  • Structures of RabGGTasesubstrate/product complexes provide insights into the evolution of protein prenylation. EMBO J. 2008 Sep 17;27(18):2444-56
    Guo Z, Wu YW, Das D, Delon C, Cramer J, Yu S, Thuns S, Lupilova N, Waldmann H, Brunsveld L, Goody RS, Alexandrov K, Blankenfeldt W
  • A cost-effective amino-acid-type selective isotope labeling of proteins expressed in Leishmania tarentolae. J. Biomol. Struct. & Dynamics. (2009)26(6):755-61
    Foldynova-Trantirkova S., Matulova J., Dotsch V., Lohr F., Cirstea I., Alexandov K., Breitling R., Lukes J., Trantirek L
  • Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. Nat Chem Biol. 2009 Apr;5(4):227-35
    Nguyen UT, Guo Z, Delon C, Wu Y, Deraeve C, Fränzel B, Bon RS, Blankenfeldt W, Goody RS, Waldmann H, Wolters D, Alexandrov K
  • Biophysical analysis of the interaction of Rab6a GTPase with its effector domains. J Biol Chem. 2009 Jan 30;284(5):2628-35
    Bergbrede T, Chuky N, Schoebel S, Blankenfeldt W, Geyer M, Fuchs E, Goody RS, Barr F, Alexandrov K
  • Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli. Protein Expr Purif. 2009 Jun;65(2):190-5
    Bleimling N, Alexandrov K, Goody R, Itzen A
  • Famesylation of Pex19p is Required for its Structural Integrity and Function in Peroxisome Biogenesis. J Biol Chem. 2009 284(31):20885-96
    Rucktäschel R, Thoms S, Sidorovitch V, Halbach A, Pechlivanis M, Volkmer-Engert R, Alexandrov K, Kuhlmann J, Rottensteiner H, Erdmann R
  • Species-independent translational leaders facilitate cell-free expression. Nat Biotechnol. 2009 Aug;27(8):747-52
    Mureev S, Kovtun O, Nguyen UT, Alexandrov K
  • Structure of the Disordered C-terminus of Rab7 GTPase Induced by Binding to the Rab Geranylgeranyl Transferase Catalytic Complex Reveals the Mechanism of Rab Prenylation. J Biol Chem. 2009 May 8;284(19): 13185-92
    Wu YW, Goody RS, Abagyan R, Alexandrov K
 
 

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