Molecular and cellular characterization of molecular models of attentiondeficit/ hyperactivity disorder
Final Report Abstract
To summarize, we succeeded in adding knowledge regarding the behavioral phenotype and expression profile of some well-known, but also of some new potential mouse models for ADHD. We could highlight the role of synaptic proteins as their gene expression profile could be shown to be altered in consequence of different genotypes and/or MPH treatment and that some of these MPH effects seem to be independent of the availability of the DAT. Additionally, using the Zebrafish model we obtained first insights into the behavioral consequences of diminished expression levels of the putative adhesion-G protein-coupled receptor LPHN3, a recently discovered susceptibility gene for ADHD. And finally, we could demonstrate the potential of peripherally expressed genes as biomarkers that could be used to diagnose ADHD and improve the treatment of ADHD in the future.
Publications
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(2007) Behavioral and expressional phenotyping of NOS1 knockdown animals. J Neural Transm Suppl. 72: 69-85
Wultsch T, Chourbaji S, Fritzen S, Kittel S, Grünblatt E, Gerlach M, Gutknecht L, Chizat F, Golfier G. Schmitt A, Gass P, Lesch KP, Reif A
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(2010) Effects of methylphenidate: the cellular point of view. ADHD Atten Def Hyper Disord 2: 225-232
Bartl J, Link P, Schlosser C, Gerlach M, Schmitt A, Walitza S, Riederer P, Grünblatt E
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(2012) Pilot study: potential transcription markers for adult attention-deficit hyperactivity disorder in whole blood. Atten Defic Hyperact Disord 4: 77-84
Gruenblatt E, Geißler J, Jacob C, Renner T, Müller M, Bartl J, Gross-Lesch S, Riederer P, Lesch KP, Walitza S, Gerlach M, Schmitt A
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(2012) The ADHD-susceptibility gtene lphn.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development. Mol Psychiatry 17: 946-54
Lange M, Norton W, Coolen M, Chaminade M, Merker S, Proft F, Schmitt A, Vernier P, Lesch KP, Bally-Cuif L
