Recombinant adeno-associated virus-mediated transgene delivery into porcine organs to allow immunological modifications of xenografts

• Applicant: Professor Dr. Michael Hallek
• Subject Area: Cardiac and Vascular Surgery
• Term: from 2004 to 2008
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5470814

• Final Report Year: 2008

Final Report Abstract

No abstract available

Publications

• (2005). Adeno-associated virus serotypes 1 to 5 mediated tumor cell directed gene transfer and improvement of transduction efficiency. J Gene Med 7(11), 1429-38
  Hacker, U, T., L. Wingenfeld, D. Kofler, N. K. Schuhmann, S. Lutz, T. Herold, S.B. King, F. M. Gerner, L. Perabo, J. Rabinowitz, D. M. McCarty, R. J. Samulski, M. Hallek, and H. Büning
  
• International Congress of Xenotransplantation (IXA), Göteburg, Schweden (2005). Adeno-associated virus serotype 2 efficiently transduces primary porcine endothelial cells
  N. Schuhmann, L. Burdorf, U. Hacker, B. Reichart, M. Schmoeckel, B. Petersen, H. Niemann, M. Hallek, H. Büning
  
• (2006). Heparan Sulfate Proteoglycan binding properties of Adeno-Associated Virus retargeting mutants and consequences for their in vivo tropism. J. of Virol. 80 (14), 7265-9
  Perabo, L., D. Goldnau, K. White, J. Endell, J. Boucas, S. Humme, L. M. Work, H. Janicki, M. Hallek, A. H. Baker, H. Büning
  
• International Symposium on Xenotransplantation, June 8th-9th, 2006, Robert Koch Institute, Berlin, Germany. AAV - a promising vector with secrets
  N. K. Schuhmann, L. Burdorf, B. Petersen, W. Kues, H. Niemann, M. Seifert, B. Reichart, M. Schmoeckel, M. Hallek and H. Büning
  
• International Symposium on Xenotransplantation, June 8th-9th, 2006, Robert Koch Institute, Berlin, Germany. AAV-mediated gene transfer into cardiac endothelial cells in heterotopic heart transplantation models
  L. Burdorf, N. Schuhmann, H. Büning, J. Postrach, A. Schulz, M. Köhn, E. Thein, M. Hallek, B. Reichart and M. Schmoeckel
  
• (2007). AAV-mediated gene transfer to cardiac cells in a heterotopic rat heart transplantation model. Transplant Proc 39(2), 567-8
  Schuhmann, N., L. Burdorf, J. Postrach, E. Thein, M. Hallek, B. Reichart, H. Büning, and M. Schmoeckel