Proximal-tubuläre Toxizität durch Cadmium-metallothionein: Rolle der Rezeptor-vermittelten Endozytose, des Vesikeltraffickings, und des Iysosomalen DMT1

• Applicant: Professor Dr. Frank Thévenod, Ph.D.
• Subject Area: Anatomy and Physiology
• Term: from 2004 to 2007
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5429134

• Final Report Year: 2008

Final Report Abstract

No abstract available

Publications

• Divalent metal transporter 1 in the kidney proximal tubule is expressed in late endosomes/lysosomal membranes: implications for renal handling of protein-metal complexes. Am J Physiol Renal Physiol 2006; 290: F1525-F1533
  Abouhamed M, Gburek J, Liu W, et al.
  
• Megalm-dependent internalization of cadmium-metallothionein and cytotoxicity in cultured renal proximal tubule cells. J Pharmacol Exp Ther 2006; 318: 782-791
  Wolff NA, Abouhamed M, Verroust PJ, et al.
  
• Knockdown of endosomal/lysosomal divalent metal transporter 1 by RNA interference prevents cadmium-metallothionein-1 cytotoxicity in renal proximal tubule cells. Am J Physiol Renal Physiol 2007; 293: F705-712
  Abouhamed M, Wolff NA, Lee WK, et al.