Molekulare Mechanismen der infektiösen Aufnahme und des zellulären Transports von Hepatitis B-Viren und deren Bedeutung für den viralen Wirts- und Leber- tropismus

Applicant Privatdozent Dr. Hüseyin Sirma

Subject Area Virology

Term from 2004 to 2009

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 5432012

Final Report Year 2009

Final Report Abstract

No abstract available

Itinerary of hepatitis B viruses: delineation of restriction points critical for infectious entry. J Virol 2004; 78: 8289-300
Funk A, Mhamdi M, Lin L, Will H, Sirma H
Nuclear translocation of papillomavirus minor capsid protein L2 requires Hsc70. J Virol 2004; 78: 5546-5553
Florin L, Becker KA, Sapp C, Lambert C, Sirma H, Muller M, Streeck RE, Sapp M
Evidence from nature: interspecies spread of avian hepatitis B viruses. J Gen Virol 2005; 86; 1335-42
Lin L, Prassolov A, Funk A, Quinn L, Hohenberg H, Frölich K, Newbold J, Ludwig A, Will H, Sirma H, Steinbach F
Identification of a novel structural motif crucial for infectivity of hepatitis B viruses. Proc Natl Acad Sei USA 2006; 103: 1630-34
Stoeckl L, Funk A, Kopitzki A, Brandenburg B, Oess S, Will H, Sirma H, Hildt E
pH-independent entry and sequential endosomal sorting are major determinants for hepadnaviral infection. Hepatology 2006; 44: 685-93
Funk A, Mhamdi M, Hohenberg H, Will H and Sirma H
Assembly and budding of a hepatitis B virus is mediated by a novel type ofintracellular vesicles. Hepatology 2007; 46: 95-106
Mhamdi M, Funk A, Hohenberg H, Will H, Sirma H
Avian Hepatitis B Viruses: Molecular and Cellular Biology, Phylogenesis and Host Tropism. W J Gastroenterol 2007; 13:91-103
Funk A, Mhamdi M, Will H and Sirma H
Duck Hepatitis B Virus Requires Cholesterol for Endosomal Escape during Virus Entry. J Virol 2008; 82: 10532-42
Funk A, Mhamdi M, Hohenberg H, Heeren J, Reimer R, Lambert C, Prange R, Sirma H