Mechanismus der Entstehung und Progression von Papillomvirus-induzierten Tumoren

Applicant Professor Dr. Thomas Iftner

Subject Area Virology

Term from 2004 to 2007

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 5432790

Final Report Year 2009

Final Report Abstract

No abstract available

Papillomavirus E2 protein induces expression of the matrix metalloproteinase-9 via the extracellular signal-regulated kinase/activator protein-1 signaling pathway. Cancer Res. 2005 Dec 15;65(24):11613-21
Behren A, Simon C, Schwab RM, Loetzsch E, Brodbeck S, Huber E, Stubenrauch F, Zenner HP, Iftner T
Papillomavirus E2 protein induces expression of the matrix-metalloproteinase 9 via the ERK/AP-1 signalling pathway. Cancer Res. 15: 11613-11621,2005
A. Behren, C. Simon, R. M. Schwab, E. Loetzsch, S. Brodbeck, E. M. Huber, F. Stubenrauch, H.P. Zenner, T. Iftner
The p38 SAPK Pathway is required for Ha-Ras induced in-vitro invasion of NIH3T3 cells. Exp. Cell Res. 303: 321-30, 2005
A. Behren, G. Vucelic, H. Loewenheim, S. Preyer, H. P. Zenner, C. Simon
AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in a rabbit papillomavirus cancer model. Virus Research, 139:100-105, 2008
Muehlen, S., Behren, A., Iftner, T., Plinkert, P.K., Simon, C.
AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells. Virus Res. 2009 Jan;139(1):100-5
Mühlen S, Behren A, Iftner T, Plinkert PK, Simon C