Analysis of the heat stress transcription factors network of Arabidopsis thaliana

• Antragsteller: Professor Dr. Pascal von Koskull-Döring
• Fachliche Zuordnung: Zell- und Entwicklungsbiologie der Pflanzen
• Förderung: Förderung von 2004 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5435214

• Erstellungsjahr: 2008

Zusammenfassung der Projektergebnisse

Compared to other eukaryotes with 1-3 heat stress transcription factors (Hsf), the plant Hsf family shows a striking multiplicity with more than 20 members. Despite many conserved features, members of the Hsf family show strong diversification of expression pattern and function within the family. Research on Arabidopsis Hsfs opened a new era with genome-wide transcriptome profiling in combination with the availability of knock-out lines. The output from these analyses provides increasing evidence that individual Hsfs have unique functions as part of different signal transduction pathways operating in response to environmental stress as well as during development. In the period funded we could decipher three specific pathways including Hsfs A2, A3 with distinct roles in the heat stress response and HsfA9 as a key regulator during seed development. Furthermore we participated in a review about the heat stress response in plants as well as about the diversification within the Hsf family.

Projektbezogene Publikationen (Auswahl)

• (2006). The heat stress transcription factor HsfA2 serves as a regulatory amplifier of a subset of genes in the heat stress response in Arabidopsis. Plant Mol. Biol., 60: 759-772
  Schramm, F., Ganguli, A., Kiehlmann, E., Englich, G., Walch, D., and von Koskull-Döring, P.
  
• (2007). A novel transcriptional cascade regulating expression of heat stress proteins during seed development of Arabidopsis. Plant Cell, 19, 182-195
  Kotak, S., Vierling, E., Bäumlein, H., and von Koskull-Döring, P.
  
• (2007). Complexity of the Heat stress response in plants. Curr. Opin. Plant. Biol., 10:310-316
  Kotak, S., Larkindale, J., Lee, U., von Koskull-Döring, P., Vierling. E., and Scharf, K.D.
  
• (2007). The diversity of plant heat stress transcription factors. Trends Plant Set., 12:452-457
  von Koskull-Döring, P., Scharf, K.D., and Nover L.
  
• (2008). A cascade of transcription factor DREB2A and heat stress transcription factor HsfA3 regulates the heat stress response of Arabidopsis. Plant J., 53, 264-274
  Schramm, F., Larkindale, J., Kiehlmann, E., Ganguli, A., Englich, G., Vierling, E., and von Koskull-Döring, P.