Duplex-Oligodesoxynucleotide mit C-glycosidisch gebundenen Basensurrogaten zur Untersuchung des Basen-Ausklapp-Mechanismus und selektiven Inhibition von DNA-Methyltransferasen

• Applicant: Professor Dr. Oliver Seitz
• Subject Area: Biological and Biomimetic Chemistry
• Term: from 2004 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5439830

• Final Report Year: 2010

Final Report Abstract

No abstract available

Publications

• "Aromatic DNA Base Surrogates - Abasic Site Stabilization and High-Affinity Binding to a Base- Flipping DNA-Methyltransferase". Pure & Appl. Chem. 2004, 76, 1563–1570
  I. Singh, C. Beuck, A. Bhattacharya, W. Hecker, V.S. Parmar, E. Weinhold, O. Seitz
  
• "Concise synthesis of aryl-C-nucleosides by Friedel-Crafts alkylation". Org. Biomol. Chem. 2005, 3, 4233–4238
  S. Hainke, S. Arndt, O. Seitz
  
• “Diastereoselective Synthesis of β-C-Arylnucleosides from 1,2-Anhydrosugars". Org. Lett. 2006, 4319–4322
  I. Singh, O. Seitz
  
• “Synthesis of C-Aryl-Nucleosides and O-Aryl-Glycosides via Cuprate Glycosylation". J. Org. Chem. 2007, 72, 8811-8819
  S. Hainke, I. Singh, J. Hemmings, O. Seitz
  
• “Binaphthyl-DNA: Stacking and Fluorescence of a Nonplanar Aromatic Base Surrogate in DNA". Angew. Chem. 2009, 131, 8399 – 8402; Angew. Chem. Int. Ed. 2009, 48, 8250 – 8253
  S. Hainke, O. Seitz