Structural studies on factor assisted protein folding and targeting

• Antragstellerin: Professorin Paola Fucini, Ph.D.
• Fachliche Zuordnung: Strukturbiologie
• Förderung: Förderung von 2005 bis 2011
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5442577

• Erstellungsjahr: 2015

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2008) The Oxazolidinone Antibiotics perturb the Ribosomal Peptidyl-transferase Center and Effect tRNA Positioning. PNAS 105: 13339-13344
  Wilson D.N., Schluenzen F., Harms J.M., Starosta A.L., Connell S.R. and Fucini P.
  
• (2008) Translational regulation via L11: Molecular switches on the ribosome turned on and off by thiostrepton and micrococcin. Mol Cell, 30: 26-38
  Harms J.M., Wilson D.N., Schluenzen F., Connell S.R., Stachelhaus T., Zaborowska Z., Spahn C.M.T. and Fucini P.
  
• (2008). A new tRNA-intermediate revealed on the ribosome during EF4-mediated backtranslocation. NSMB 15: 910-915
  Connell S.R., Topf M., Qin Y., Wilson D.N., Mielke T., Fucini P., Nierhaus K. and Spahn C.M.T.
  
• (2009) Probing Protein Folding on the Ribosome by Solution State NMR Spectroscopy. Journal of Biomolecular Structure and Dynamic 26: 846-846
  Hsu STD, Cabrita LD, Fucini P, Christodoulou J, Dobson CM
  
• (2009) Probing Side-Chain Dynamics of a Ribosome-Bound Nascent Chain Using Methyl NMR Spectroscopy. J Am Chem Soc 131: 8366-
  Hsu STD, Cabrita LD, Fucini P, Christodoulou J, Dobson CM
  
• 2009) Structure, Dynamics and Folding of an Immunoglobulin Domain of the Gelation Factor (ABP-120) from Dictyostelium discoideum. J Mol Biol 388: 865-879
  Hsu STD, Cabrita LD, Fucini P, Dobson CM, Christodoulou J
  
• (2010) Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites. Nature 468, 713-6
  Ratje, A.H., Loerke, J., Mikolajka, A., Brunner, M., Hildebrand, P.W., Starosta, A.L., Donhofer, A., Connell, S.R., Fucini, P., Mielke, T., Whitford, P.C., Onuchic, J.N., Yu, Y., Sanbonmatsu, K.Y., Hartmann, R.K., Penczek, P.A., Wilson, D.N. & Spahn, C.M.
  
• (2010) PSRP1 is not a ribosomal protein, but a ribosome-binding factor that is recycled by the ribosome-recycling factor (RRF) and elongation factor G (EF-G) J Biol Chem 285: 4006-14
  Sharma M.R., Dönhöfer A., Barat C., Marquez V., Datta P.P., Fucini P., Wilson D.N., Agrawal R.K.
  
• (2013) Solid-state NMR enhanced by dynamic nuclear polarization as a novel tool for ribosome structural biology. J Biomol NMR. 56: 85-93
  Gelis I., Vitzthum V., Dhimole N., Caporini M.A,. Schedlbauer A., Carnevale D., Connell S.R., Fucini P., and Bodenhausen G.
  (Siehe online unter https://doi.org/10.1007/s10858-013-9721-2)
• Structural Characterization of an Alternative Mode of Tigecycline Binding to the Bacterial Ribosome. Antimicrobial Agents and Chemotherapy, Vol 59, No 5, May 2015, pp. 2849–2854
  Andreas Schedlbauer, Tatsuya Kaminishi, Borja Ochoa-Lizarralde, Neha Dhimole, Shu Zhou, Jorge P. López-Alonso, Sean R. Connell, Paola Fucini
  (Siehe online unter https://doi.org/10.1128/AAC.04895-14)