Project Details
Projekt
Bedeutung des stromal cell-derived factor 1alpha in der Neointimabildung und Remodeling bei akzelerierter Atherosklerose
Applicant
Professor Dr. Christian Weber
Subject Area
Cardiology, Angiology
Term
from 2004 to 2010
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5443815
Final Report Year
2010
Final Report Abstract
No abstract available
Publications
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Expression of HIF-1alpha in injured arteries controls SDF-1alpha mediated neointima formation in apolipoprotein E deficient mice. Arterioscler Thromb Vasc Biol. 2007;27:2540-2547
Karshovska E, Zernecke A, Sevilmis G, Millet A, Hristov M, Cohen CD, Schmid H, Krotz F, Sohn HY, Klauss V, Weber C, Schober A
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A small molecule CXCR4 antagonist inhibits neointima formation and smooth muscle progenitor cell mobilization after arterial injury. J. Thromb. Haemost. 2008;6:1812-5
Karshovska E, Zagorac D, Zernecke A, Weber C, Schober A
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Accumulation of myeloperoxidase-positive neutrophils in atherosclerotic lesions in LDLR-/- mice. Arterioscler Thromb Vasc Biol. 2008;28:84-9
van Leeuwen M et al.
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Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis. Circ Res. 2008;102:209-17
Zernecke A, Bot I, Djalali-Talab Y, Shagdarsuren E, Bidzhekov K, Meiler S, Krohn R, Schober A, Sperandio M, Soehnlein O, Bornemann J, Tacke F, Biessen EA, Weber C
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Role of human smooth muscle cell progenitors in atherosclerotic plaque development and composition. Cardiovasc Res. 2008;77:471-80
Zoll J et al.
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Apoptotic bodies unleash vasculoprotective CXCL12 expression through microRNA-126. Science Sign. 2009;2:ra81
Zernecke A, Bidzhekov K, Noels H, Gan L, Denecke B, Shagdarsuren E, Hristov M, Köppel T, Nazari Jahantigh M, Wang S, Olson EN, Schober A, Weber C
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Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells. Eur Heart J. 2009;30:584-93
Stellos K et al. & Gawaz M
