Sympathikus-Hyperaktivität als pathogenetischer Mechanismus der Spontan-bakteriellen Peritonitis (SBP) und der Infektanfälligkeit bei Leberzirrhose

• Applicant: Privatdozent Dr. Reiner Wiest
• Subject Area: Gastroenterology
• Term: from 2005 to 2010
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5445431

• Final Report Year: 2008

Final Report Abstract

No abstract available

Publications

• Ablation of the sympathetic nervous system decreases gram-negative and increases gram-positive bacterial dissemination; key roles for tumor necrosis factor/phagocytes and interleukin-4/lymphocytes. J Infect Dis 2005; 192(4):560- 572
  R.H. Straub, Pongratz G, Weidler C, Linde HJ, Kirschning CJ, Gluck T et al.
  
• The role of the sympathetic nervous system in intestinal inflammation. Gut 2006; 55:1640- 1649
  R.H. Straub, R. Wiest, UG Strauch, P Härle, J. Schölmerich
  
• Aggravation of DSS-induced colitis after chronic subordinate colony (CSC) housing is partially mediated by adrenal mechanisms. Stress 2008; 11(3):225-234
  Reber SO, Obermeier F, Straub R.H., Veenema AH, Neumann ID
  
• Anti-Inflammatory Role of Sympathetic Nerves in Chronic Intestinal Inflammation. Gut 2008; 57(7): 911-921
  Straub R.H., Grum F, Strauch UG, Capellino S, Bataille F, Bleich A et al.
  
• Bacterial translocation increases phagocytic activity of polymorphonuclear leucocytes in portal hypertension: priming independent from liver cirrhosis. Liver International 2008; 28(8): 1149-57
  H. Neugebauer, P. Hartmann, S. Krenn, T. Glück, J. Schölmerich, R.H. Straub, R. Wiest
  
• Chemical sympathectomy increases susceptibility to ocular herpes simplex virus type 1 infection. J Neuroimmunol 2008; 197(1): 37-46
  Templeton A, Nguyen G, Ash JD, Straub R.H., Carr DJ
  
• Uncoupling of sympathetic and hypothalamic-pituitary-adrenal axis in liver cirrhosis J. Gastro. Hepatol. 2008
  R. Wiest, Moleda, L., Hellerbrand, C., Zietz, B., Straub R.H., Schölmerich J.