Hochauflösende optische Kohärenztomographie für die virtuelle Histologie: Funktionelle Analytik und numerische Verfahren zur Kontrast- und Auflösungssteigerung

• Antragsteller: Professor Dr. Heinrich Kurz (†); Professor Dr.-Ing. Tobias G. Noll
• Fachliche Zuordnung: Medizinische Physik, Biomedizinische Technik
• Förderung: Förderung von 2005 bis 2010
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5446713

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Bladder tissue differentiation by high-resolution optical coherence tomography, 28th Congress of the Société Internationale d’Urologie, Cape Town, South Africa (2006)
  J. Grosse, B. Hermes, J. Bornemann, F. Spöler, M. Först, and G. Jakse
  
• Characterization of healthy urothelium and bladder cancer using high-resolution optical coherence tomography, 58. Kongress der Deutschen Gesellschaft für Urologie e.V., Hamburg, Germany (2006)
  B. Hermes , J. Bornemann, A. Naami, J. Grosse, F. Spöler, M. Först, R. Knüchel and G. Jakse
  
• High-tech pathology, 16th Annual Conference of the DGfZ, Leipzig, Germany, Cell Proliferation 39, 339-378 (2006)
  R. Knüchel, E. Dahl, G. Brockhoff, M. Plander, F. Spöler, M. Först, H. Stepp and R. Krieg
  
• Non-invasive imaging of normal and neoplastic urothelium by high-resolution optical coherence tomography, CNIO Meeting on Bladder Cancer, Madrid, Spain (2006)
  B. Hermes, F. Spöler, J. Bornemann, A. Naami, J. Grosse, M. Först, R. Knüchel, and G. Jakse
  
• An open label trial evaluating the use of Optical Coherence Tomography and Photodynamic Diagnosis to demonstrate regression of actinic keratosis during treatment with 3% diclofenac in 2.5% hyaluronic acid gel, 16th EADV Congress, Vienna, Austria, (2007)
  F. Abuzahra, S. Neugebauer, F. Spöler, M. Först, H.F. Merk, D. Höller-Obrigkeit
  
• Dynamic analysis of chemical eye burns using high resolution optical coherence tomography, J. Biomed. Opt. 12, 041203 (2007)
  F. Spöler, M. Först, H. Kurz, M. Frentz, and N. Schrage
  
• Dynamic imaging of penetration and decontamination after chemical eye burn using optical coherence tomography, European Conference on Biomedical Optics, Munich, Germany, Proc. SPIE Int. Soc. Opt. Eng. 6627, 66270B (2007)
  F. Spöler, M. Först, H. Kurz, M. Frentz and N.F. Schrage
  
• HF penetration into the eye - observation of early eye burns by optical coherence tomography, International Congress on Burns, Cologne, Germany, (2007)
  F. Spöler, M. Först, H. Kurz
  
• High-resolution medical imaging by optical coherence tomography, in Workshop Nanometrology, Abstract book, p.31, Torino, Italy, (2007)
  M. Först
  
• High-resolution optical coherence tomography – non-invasive cross-sectional imaging for ophthalmological and dermatological applications, The Royal Photographic Society, Medical and Forensic Imaging, London, GB (2007)
  F. Spöler, M. Först, D. Hoeller-Obrigkeit, F. Abuzahra, M. Frentz, N. Schrage, and H. Kurz
  
• Highresolution Optical Coherence Tomography of tumor spheroids and human bladder tissue, 91. Jahrestagung Deutsche Gesellschaft für Pathologie, Magdeburg, Germany, (2007)
  Naami, B. Hermes, F. Spöler, J. Bornemann, G. Jakse, and R. Knüchel
  
• Non-destructive vital histological depiction of malignant melanoma by high resolution optical coherence tomography, 37th Meeting of the European Society for Dermatological Research, Zürich, Switzerland (2007)
  D. Höller-Obrigkeit, F. Spöler, M. Först, H. Merk, C. Beckmann, and F. Abuzahra
  
• Optical coherence tomography – a new method to analyse the dynamics of chemical eye burns, International Congress on Burns, Cologne, Germany, (2007)
  F. Spöler, M. Först, H. Kurz
  
• Real-time Speckle Reduction in High-Resolution OCT Imaging, Posters’07, Prag, Czech Republic (2007)
  H. Luecken, G. Tech, R. Schwann, and G. Kappen
  
• Simultaneous dual-band ultra-high resolution optical coherence tomography, Opt. Express 15, 10832-10841 (2007)
  F. Spöler, S. Kray, P. Grychtol, B. Hermes, J. Bornemann, M. Först, and H. Kurz
  
• Stick Based Speckle Reduction for Real-Time Processing of OCT Images on an FPGA, Acta Polytechnica Journal of Advanced Engineering, vol. 47, No. 4-5, (2007)
  H. Luecken, G. Tech, R. Schwann, G. Kappen
  
• Ultrahigh resolution optical coherence tomography at two infrared wavelength regions using a single light source, European Conference on Biomedical Optics, Munich, Germany, Proc. SPIE Int. Soc. Opt. Eng. 6627, 662704 (2007)
  F. Spöler, S. Kray, P. Grychtol, B. Hermes, J. Bornemann, M. Först, and H. Kurz
  
• Adaptive Kernel algorithm for FPGA-based speckle reduction, SPIE Medical Imaging Conference, San Diego, USA, Proc. SPIE Int. Soc. Opt. Eng. 6914, 691424 (2008)
  G. Tech, R. Schwann, G. Kappen, M. Först, T. G. Noll
  
• Analysis of hydrofluoric acid penetration and decontamination of the eye by means of timeresolved optical coherence tomography, Burns 34, 549-555 (2008)
  F. Spöler, M. Frentz, M. Först, H. Kurz, and N.F. Schrage
  
• Caustic Soda and H2SO4 decontamination of the cornea ex vivo demonstrated via OCT, XXVIII International Congress of the European Association of Poisons Centres and Clinical Toxicologists, Seville, Spain (2008)
  F. Spöler, M. Först, M. Frentz, F. Kurz, N. Schrage
  
• Contrast enhancement in ultrahigh resolution optical coherence tomography (UHR-OCT) on bladder tissue using two wavelength bands simultaneously, 60. Kongress der Deutschen Gesellschaft für Urologie e.V., Stuttgart, Germany (2008)
  J. Bornemann, F. Spöler, S. Kray, A. Naami, M. Först, R. Knüchel, G. Jakse, J. Grosse
  
• Dual femtosecond laser multiheterodyne optical coherence tomography, Opt. Lett. 33, 2092-2094 (2008)
  S. Kray, F. Spöler, M. Först, and H. Kurz
  
• Imaging of actinic porokeratosis by optical coherence tomography (OCT). Hautarzt 59: 877-9 (2008)
  V. von Felbert, M. Neis, M. Megahed, F. Spöler
  
• Neue Methoden und Applikationen für die hochauflösende optische Kohärenztomographie, Dissertation, RWTH Aachen, Verlag Dr.Hut (2008)
  F. Spöler
  
• Supercontinuum based ultrahigh resolution Fourier domain optical coherence tomography, in OSA Biomedical Optics Topical Meetings on CD-ROM, The Optical Society of America, St. Petersburg, USA (2008)
  S. Kray, F. Spöler, M. Först, H. Kurz
  
• Visualization of the basement membrane zone of the urinary bladder by optical coherence tomography: feasibility of non-invasive evaluation of tumor invasion, Urology 72, 677-681 (2008)
  B. Hermes, F. Spöler, A. Naami, J. Bornemann, M. Först, J. Grosse, G. Jakse, and R. Knüchel
  
• Dual Femtosecond Laser Based Multiheterodyne Low Coherence Interferometry, Conference on Lasers and Electro-Optics (CLEO), Baltimore, Maryland, USA (2009)
  S. Kray, F. Spöler, M. Först, and H. Kurz
  
• High Resolution Simultaneous Dual-Band Spectral Domain Optical Coherence Tomography, European Conference on Biomedical Optics, Munich, Germany (2009)
  S. Kray, F. Spöler, M. Först, and H. Kurz
  
• High-resolution simultaneous dualband spectral domain optical coherence tomography, Opt. Lett. 34, 1970-1972 (2009)
  S. Kray, F. Spöler, M. Först, and H. Kurz
  
• Improved contrast in clinical imaging. SPIE Newsroom, technical article (2009)
  S. Kray, F. Spöler, H. Kurz
  
• Pilot study: optical coherence tomography as a non-invasive diagnostic perspective for real time visualisation of onychomycosis. Mycoses, early view
  F. Abuzahra, F. Spöler, M. Först, R. Brans, S. Erdmann, H. F. Merk, D. Hoeller Obrigkeit