Die Charakterisierung der Titin-Filamente in der glatten Muskulatur (gem mit. LA 668/9-1)

• Applicant: Privatdozent Dr. Dietmar Labeit
• Subject Area: Gynaecology and Obstetrics
• Term: from 2005 to 2008
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5447086

• Final Report Year: 2008

Final Report Abstract

No abstract available

Publications

• Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their conserved interaction with filamins. J Mol Biol 2006: 362, 664-681
  Labeit S, Lahmers S, Burkart C, Fong C, McNabb M, Witt S, Witt C, Labeit D, Granzier H
  
• A comparative proteome analysis of human metaphase chromosomes isolated from two different cell lines reveals a set of conserved chromosome-associated proteins. Genes & Cells 2007: 12, 269-284
  Takata H, Uchiyama S, Nakamura N, Nakashima S, Kobayashi S, Sone T, Kimura S, Lahmers S, Granzier H, Labeit S, Matsunaga S, Fukui K
  
• Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle. Am J Physiol Regul Integr Comp Physiol. 2007: 293, R557-567
  Granzier H, Radke M, Royal J, Wu Y, Irving TC, Gotthardt M, Labeit S
  
• Structure-function relations of the giant elastic protein titin in striated and smooth muscle cells. Muscle & Nerve 2007: 36, 740-755
  Granzier H, Labeit S.
  
• A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain. Proc Natl Acad Sci USA 2008: 105,1186-1191
  von Castelmur E, Marino M, Svergun DI, Kreplak L, Ucurum-Fotiadis Z, Konarev PV, Urzhumtsev A, Labeit D, Labeit S, Mayans O