The role of chromatin structure regulation in the susceptibility to transcription-blocking lesions (A03)

• Subject Area: Cell Biology ; General Genetics and Functional Genome Biology ; Bioinformatics and Theoretical Biology ; Biogerontology and Geriatric Medicine
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 520471345

DNA damage can interfere with transcription and defects in transcription-coupled repair accelerate the aging process in humans. We have established C. elegans as organismal model for studying the consequences of transcription-blocking DNA damage. Here, we will investigate the role of the SRCAP orthologue ssl-1 in regulating the response mechanisms to transcription impediments. We will assess how the regulation of gene expression and transcription elongation is influenced by SSL-1-dependent deposition of the HTZ-1/H2A.Z histone.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1678: Systems-level consequences of fidelity changes in mRNA and protein biosynthesis
• Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Björn Schumacher