Regulation of splicing fidelity in response to DNA double-strand breaks (A05)

• Subject Area: Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 520471345

This project aims to explore the complex interplay between DNA double-strand breaks and the fidelity of RNA splicing. DNA double-strand breaks trigger complex cellular responses, impacting gene expression and splicing processes. The research will delve into how DSBs impact the accuracy of splicing, examining aspects such as chromatin architecture at breaks, the role of the spliceosome, and genome-wide effects on RNA production.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1678: Systems-level consequences of fidelity changes in mRNA and protein biosynthesis
• Applicant Institution: Universität zu Köln
• Project Head: Dr. Stephanie Panier