Speed vs. fidelity: The role of nuclear RNA export under cellular stress (A07)

• Subject Area: Cell Biology ; General Genetics and Functional Genome Biology ; Bioinformatics and Theoretical Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 520471345

This combined experimental and computational project aims to unravel the complex decision-making in mRNA export routes during cellular stress, particularly oxidative stress in human cells. Utilizing advanced RNA labeling, sequencing, and CRISPR-mediated knockdown techniques (Mayer), this study performs a comprehensive systems-level analysis of the parameters of RNA metabolism (Tresch). This project will identify mechanisms related to nuclear export that the cell uses to evade RNA quality control under stress conditions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1678: Systems-level consequences of fidelity changes in mRNA and protein biosynthesis
• Applicant Institution: Universität zu Köln
• Project Heads: Dr. Andreas Mayer; Professor Dr. Achim Tresch