Neurotransmitter-Systeme als Angriffspunkte selektiver Pharmaka

• Applicant: Professor Dr. Manfred Göthert, since 3/2006 (†)
• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2005 to 2006
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5447958

• Final Report Year: 2009

Final Report Abstract

No abstract available

Publications

• Decreased agonist, but not antagonist, binding to the naturally occurring Th92Lys variant of the h5-HT7(a) receptor. Neurochem. Int. 15 (2005): 196-203
  Brüss M, Kiel S, Bönisch H, Kostanian A, Göthert M
  
• Functional investigation of the human 5-HT1A receptor gene promoter. Program No. 373.20. 2005 Abstract Viewer/Iterinary Planner, Washington, DC: Society for Neuroscience, 2005, Online
  Brüss M, Addoais A, Göthert M, Bönisch H
  
• The naturally occurring Arg219Leu variant of the human 5-HT1A receptor: impairment of signal transduction. Pharmacogenet. Genomics 47(2005): 257-264
  Brüss M, Kostanian A, Bönisch H, Göthert M
  
• WIN 55,212-2-induced reduction of cocaine hyperlocomotion: possible inhibition of 5-HT3 receptor function. Eur. J. Pharmacol. 517 (2005): 68-73
  Przegalinski E, Göthert M, Frankowska M, Filip M.
  
• 5-Hydroxytryptamine-induced contraction of human temporal arteries coexpressing 5-HT2A receptors and wild-lype or variant (Phe124Cys) 5-HT1B receptors: increased contribution of 5-HT1B receptors to the total contractile amplitude in arteries from Phel24Cys heterozygous individuals. Pharmacogenet. Genomics 16 (2006): 601-607. Erratum in Pharmacogenet. Genomics 17 (2007): 679
  Verheggen R, Werner I, Lücker A, Brüss M, Göthert M, Kaumann AJ
  
• Aequorin luminescence-based assay for 5-hydroxytryptamine (serotonin) type 3 receptor characterization. Anal. Biochem. 368 (2007): 185-92
  Walstab J, Combrink S, Brüss M, Göthert M, Niesler B, Bönisch H
  
• 5-HT receptor regulation of neurotransmitter release. Pharmacol. Rev. 59 (2007): 360-417
  Fink KB, Göthert M
  
• Cannabinoid receptor-independent inhibition by methanandamide of alpha7-nicotinic acetylcholine receptor-mediated responses in vivo. Program No. 39.22. 2007 Abstract Viewer/Iterinary Planner. San Diego, CA: Society for Neuroscience, 2007, Online
  Göthert M, Baranowska U, Godlewski B, Malinowska B
  
• Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol. Pharmacol. 72 (2007):8-17
  Niesler B, Walstab J, Combrink S, Möller D, Kapeller J, Rietdorf J, Bönisch H, Göthert M, Rappold G, Brüss, M